Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Isolated peritoneal lymphomatosis defined as post-transplant lymphoproliferative disorder after a liver transplant: A case report
Hong Beum Kim, Ran Hong, Yung Sub Na, Woo Young Choi, Sang Gon Park, Hee Jeong Lee
Hong Beum Kim, Department of Premedical Course, Chosun University School of Medicine, Gwangju 501-717, South Korea
Ran Hong, Department of Pathology, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, South Korea
Yung Sub Na, Department of Internal Medicine, Pulomonology, Chosun University Hospital, Gwangju 501-717, South Korea
Woo Young Choi, Department of Plastic and Reconstructive Surgery, Chosun University Hospital, Gwangju 501-717, South Korea
Sang Gon Park, Hee Jeong Lee, Department of Internal Medicine, Hemato-oncology, Chosun University Hospital, Gwangju 501-717, South Korea
Hee Jeong Lee, MD, PhD, Department of HematoOncology, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, South Korea
Author contributions: Kim HB were the major contributors in writing the manuscript; Na YS and Choi WY advised the manuscript; Park SG and Lee HJ were involved in drafting, writing and editing the manuscript; Lee HJ reviewed the manuscript as corresponding author; All authors read and approved the final manuscript.
Supported by the National Research Foundation of Korea, No. NRF-2017R1C1B5076793.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflict-of-interest.
CARE Checklist (2016) statement: The manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hee Jeong Lee, MD, PhD, Assistant Professor, Doctor, Department of HematoOncology, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, South Korea.
hjangel21c@hanmail.net
Telephone: +82-62-2203984 Fax: +82-62-2349653
Received: October 7, 2019
Peer-review started: October 7, 2019
First decision: October 23, 2019
Revised: October 31, 2019
Accepted: November 15, 2019
Article in press: November 15, 2019
Published online: December 26, 2019
Processing time: 79 Days and 4.3 Hours
BACKGROUND
Post-transplant lymphoproliferative disorder (PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Potential manifestations are diverse, ranging from reactive lymphoid hyperplasia to high-grade lymphoma. PTLD is usually of B-cell origin and associated with Epstein-Barr virus (EBV) infection. Herein, we describe a case of PTLD involving the peritoneal omentum. There has been only case of PTLD as a diffuse large B-cell lymphoma (DLBCL) in the peritoneum.
CASE SUMMARY
The patient was a 62-year-old man who had been receiving immunosuppressive therapy with tacrolimus since undergoing a liver transplant 15 years prior. He reported that he had experienced abdominal discomfort and anorexia 1 month prior to the current admission. Abdominal pelvic computed tomography (CT) revealed peritoneal and omental mass-like lesions without bowel obstruction. Ultrasonography-guided biopsy was performed, and he was histologically diagnosed with EBV-negative DLBCL. Positron emission tomography (PET)-CT depicted peritoneum and omentum involvement only, without any lymphadenopathy or organ masses, including in the gastrointestinal tract. Six cycles of chemotherapy with a “R-CHOP“ regimen (rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone) were administered, and PET-CT performed thereafter indicated complete remission.
CONCLUSION
This is the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.
Core tip: Post-transplant lymphoproliferative disorder (PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Herein we present the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.
