Yu Y, Zhu CF, Fu X, Xu H. Sagliker syndrome: A case report of a rare manifestation of uncontrolled secondary hyperparathyroidism in chronic renal failure. World J Clin Cases 2019; 7(22): 3792-3799 [PMID: 31799306 DOI: 10.12998/wjcc.v7.i22.3792]
Corresponding Author of This Article
Chen-Fang Zhu, MD, PhD, Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Discipline Construction Research Center of China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai 200011, China. sammizz1977@126.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2019; 7(22): 3792-3799 Published online Nov 26, 2019. doi: 10.12998/wjcc.v7.i22.3792
Sagliker syndrome: A case report of a rare manifestation of uncontrolled secondary hyperparathyroidism in chronic renal failure
Yu Yu, Chen-Fang Zhu, Xiao Fu, Hua Xu
Yu Yu, Chen-Fang Zhu, Xiao Fu, Hua Xu, Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Discipline Construction Research Center of China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai 200011, China
Author contributions: Yu Y collected the data and wrote the paper; Zhu CF was directly responsible for performing the operation and revised the paper; Fu X and Xu H designed the report and analyzed the data; all authors read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient herself for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chen-Fang Zhu, MD, PhD, Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Discipline Construction Research Center of China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai 200011, China. sammizz1977@126.com
Telephone: +86-13917603720
Received: June 12, 2019 Peer-review started: June 19, 2019 First decision: September 9, 2019 Revised: October 3, 2019 Accepted: October 15, 2019 Article in press: October 15, 2019 Published online: November 26, 2019 Processing time: 167 Days and 3.1 Hours
Abstract
BACKGROUND
Sagliker syndrome (SS) resulting from uncontrolled secondary hyperparathyroidism (SHPT) in chronic renal failure (CRF) is seldom reported.
CASE SUMMARY
A 24-year-old woman presented with asymmetric facial deformity and stature shortening. She was diagnosed with SS, SHPT, CRF, and thyroid cancer. The patient underwent a total parathyroidectomy and thyroidectomy with central lymph node dissection. The patient’s condition was stable and was discharged from the hospital.
CONCLUSION
Undergoing dialysis vintage, presenting high serum phosphate levels, and female gender may be risk factors for SS. Intramembranous ossification in the craniomaxillofacial region is possibly activated in this special pathophysiological condition. What’s more, the choice of surgery mainly depends on the treatment goal and the experience of the individual surgeon.
Core tip: This article reports one case of Sagliker syndrome, a rare complication of secondary hyperparathyroidism, which is characterized by disfiguring facial deformity, resulting in a lion-like face. We review the whole process of diagnosis and treatment in order to bring inspiration to other patients. Related articles are reviewed, and we make reasonable speculation of its risk factors. We also creatively put forward the hypothesis of its manifestation mechanisms and discuss its treatment modalities.
