Published online Nov 26, 2019. doi: 10.12998/wjcc.v7.i22.3792
Peer-review started: June 19, 2019
First decision: September 9, 2019
Revised: October 3, 2019
Accepted: October 15, 2019
Article in press: October 15, 2019
Published online: November 26, 2019
Sagliker syndrome (SS) resulting from uncontrolled secondary hyperparathyroidism (SHPT) in chronic renal failure (CRF) is seldom reported.
A 24-year-old woman presented with asymmetric facial deformity and stature shortening. She was diagnosed with SS, SHPT, CRF, and thyroid cancer. The patient underwent a total parathyroidectomy and thyroidectomy with central lymph node dissection. The patient’s condition was stable and was discharged from the hospital.
Undergoing dialysis vintage, presenting high serum phosphate levels, and female gender may be risk factors for SS. Intramembranous ossification in the craniomaxillofacial region is possibly activated in this special pathophysiological condition. What’s more, the choice of surgery mainly depends on the treatment goal and the experience of the individual surgeon.
Core tip: This article reports one case of Sagliker syndrome, a rare complication of secondary hyperparathyroidism, which is characterized by disfiguring facial deformity, resulting in a lion-like face. We review the whole process of diagnosis and treatment in order to bring inspiration to other patients. Related articles are reviewed, and we make reasonable speculation of its risk factors. We also creatively put forward the hypothesis of its manifestation mechanisms and discuss its treatment modalities.