Published online Oct 6, 2019. doi: 10.12998/wjcc.v7.i19.3132
Peer-review started: March 26, 2019
First decision: May 31, 2019
Revised: June 25, 2019
Accepted: July 3, 2019
Article in press: July 3, 2019
Published online: October 6, 2019
Parathyroid adenoma (PTA) is known as an adenomatous hyperparathyroidism syndrome. At earlier times, the major symptoms of this disease included high blood calcium and low phosphorus. PTA is a benign neuroendocrine neoplasm. We have reviewed the literature and found that it is rare for patients with hyperparathyroidism to have benign tumors with multiple organs at the same time. This report describes a patient with a PTA and four nonfunctional adenomas.
We report a case of primary hyperparathyroidism in a 39-year-old woman with multiple organ tumors. The patient was admitted to hospital because of hypercalcemia. Laboratory, imaging, and histological examinations confirmed a left parathyroid neoplasm. Right thyroid adenoma was discovered during hospitalization. She had a medical history of uterine fibroids, right benign mammary gland tumor, and meningioma. The patient recovered after surgical and conservative treatments.
Primary hyperparathyroidism with multiple organ tumors is uncommon, and further studies should be conducted to determine if there is genetic heterogeneity.
Core tip: Simultaneous occurrence of multiple tumors is rare. This article reports a patient who was admitted to hospital with hypercalcemia and finally diagnosed with a parathyroid adenoma via surgical pathology. The patient also had uterine fibroids, benign mammary gland tumor, and meningioma. After diagnosis, these tumors were all removed.