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World J Clin Cases. Sep 26, 2019; 7(18): 2675-2686
Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2675
High-resolution colonic manometry and its clinical application in patients with colonic dysmotility: A review
Yu-Wei Li, Yong-Jun Yu, Fei Fei, Min-Ying Zheng, Shi-Wu Zhang
Yu-Wei Li, Yong-Jun Yu, Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300071, China
Fei Fei, Min-Ying Zheng, Shi-Wu Zhang, Department of Pathology, Tianjin Union Medical Center, Tianjin 300071, China
Fei Fei, Shi-Wu Zhang, Nankai University School of Medicine, Nankai University, Tianjin 300071, China
Author contributions: All authors contributed equally to this manuscript with conception and design of the study, literature review and analysis, manuscript drafting, critical revision, and editing, and final approval of the submission.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shi-Wu Zhang, MD, PhD, Chief Doctor, Department of Pathology, Tianjin Union Medical Center, Jieyuan Road, Hongqiao District, Tianjin 300071, China. 30117012@nankai.edu.cn
Telephone: +86-13652136865 Fax: +86-22-87721989
Received: April 12, 2019
Peer-review started: April 12, 2019
First decision: June 28, 2019
Revised: July 26, 2019
Accepted: August 20, 2019
Article in press: August 20, 2019
Published online: September 26, 2019
Processing time: 166 Days and 1.5 Hours
Abstract

The detailed process and mechanism of colonic motility are still unclear, and colonic motility disorders are associated with numerous clinical diseases. Colonic manometry is considered to the most direct means of evaluating colonic peristalsis. Colonic manometry has been studied for more than 30 years; however, the long duration of the examination, high risk of catheterization, huge amount of real-time data, strict catheter sterilization, and high cost of disposable equipment restrict its wide application in clinical practice. Recently, high-resolution colonic manometry (HRCM) has rapidly developed into a major technique for obtaining more effective information involved in the physiology and/or pathophysiology of colonic contractile activity in colonic dysmotility patients. This review focuses on colonic motility, manometry, operation, and motor patterns, and the clinical application of HRCM. Furthermore, the limitations, future directions, and potential usefulness of HRCM in the evaluation of clinical treatment effects are also discussed.

Keywords: High-resolution colonic manometry; Constipation; High-amplitude propulsive contractions; Low-amplitude propagated contractions; Colonic dysmotility

Core tip: Colonic motility disorders are associated with numerous clinical diseases, while the detailed process and mechanism of colonic motility remain unclear. High-resolution colonic manometry (HRCM) has rapidly developed into a major technique for obtaining greater insight into the physiology and/or pathophysiology of colonic contractile activity in patients with colonic motility disorders. This review focuses on colonic motility, manometry, operation, and motor patterns, as well as the clinical application of HRCM, and aims to assess whether the results of HRCM have led to the establishment of diagnostic criteria and/or have helped guide the treatment of patients.