Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2406
Peer-review started: March 26, 2019
First decision: May 31, 2019
Revised: July 9, 2019
Accepted: July 20, 2019
Article in press: July 20, 2019
Published online: August 26, 2019
Processing time: 155 Days and 10.9 Hours
Syphilis is a common sexually transmitted disease caused by the Treponema pallidum (T. pallidum). Malignant syphilis is a rare presentation of secondary syphilis. Here, we present a case diagnosed with malignant syphilis accompanied with neurosyphilis.
A 56-year-old man present with a 2-mo history of spreading ulcerous and necrotic papules and nodules covered with thick crusts over the face, trunk, extremities, and genitalia. The patient was diagnosed with malignant syphilis accompanied by neurosyphilis based on the characteristic morphology of the lesions, positive serological and cerebrospinal fluid tests for syphilis, brain magnetic resonance imaging, and histopathology, along with resolution of the lesions following the institution of penicillin therapy. The lesions and neurological condition successfully resolved after a course of treatment with penicillin.
We suggest that neurosyphilis should be considered whenever people have psychiatric symptoms without cutaneous lesions or human immunodeficiency virus.
Core tip: We present a 53-year-old malnourished man with a two-month history of spreading ulcerative and necrotic cutaneous lesions with psychiatric symptoms. The patient was diagnosed with malignant syphilis accompanied by neurosyphilis based on the characteristic morphology, positive serological and cerebrospinal fluid tests, and histopathology, with resolution of the lesions following penicillin therapy. We report the case to emphasize the diagnosis of the disease, and its association not only with human immunodeficiency virus (HIV), but also with other poor health conditions, specifically malnutrition. We suggest that neurosyphilis should be considered whenever people have psychiatric symptoms even in case of no cutaneous lesions or HIV infection.