Da Dalt G, Friziero A, Grego A, Serafini S, Fassina A, Blandamura S, Sperti C. Adrenal metastasis from endometrial cancer: A case report. World J Clin Cases 2019; 7(14): 1844-1849 [PMID: 31417930 DOI: 10.12998/wjcc.v7.i14.1844]
Corresponding Author of This Article
Cosimo Sperti, MD, Professor, Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, via Giustiniani 2, Padua 35128, Italy. cosimo.sperti@unipd.it
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2019; 7(14): 1844-1849 Published online Jul 26, 2019. doi: 10.12998/wjcc.v7.i14.1844
Adrenal metastasis from endometrial cancer: A case report
Gianfranco Da Dalt, Alberto Friziero, Andrea Grego, Simone Serafini, Ambrogio Fassina, Stella Blandamura, Cosimo Sperti
Gianfranco Da Dalt, Alberto Friziero, Andrea Grego, Simone Serafini, Cosimo Sperti, Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Padua 35128, Italy
Ambrogio Fassina, Stella Blandamura, Department of Medicine, Surgical Pathology and Cytopathology, University of Padua, Padua 35128, Italy
Author contributions: Da Dalt G and Friziero A conceived the study, conducted the literature search, and drafted the manuscript; Grego A and Serafini S helped with patient management; Friziero A and Blandamura S completed the pathological diagnosis and immunoassays; Sperti C supervised the study and critically revised the paper. All Authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2013), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Cosimo Sperti, MD, Professor, Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, via Giustiniani 2, Padua 35128, Italy. cosimo.sperti@unipd.it
Telephone: +39-49-8218845 Fax: +39-49-8218821
Received: March 19, 2019 Peer-review started: March 19, 2019 First decision: April 18, 2019 Revised: April 30, 2019 Accepted: May 11, 2019 Article in press: May 11, 2019 Published online: July 26, 2019 Processing time: 129 Days and 14.3 Hours
Abstract
BACKGROUND
Metastases to adrenal glands originate principally from lung, breast, or gastrointestinal cancers, followed by malignant melanoma and thyroid neoplasms. We present an unusual case of uterine cancer metastasizing to the adrenal glands with a review of the English literature on the management of this rare disease.
CASE SUMMARY
A 53-year-old Caucasian woman with a history of endometrial cancer (grade 2; International Federation of Gynecology and Obstetrics III A) was hospitalized in November 2017 for a left adrenal mass found on a follow-up computed tomography scan 3 years after her gynecological surgery. Laboratory test results were normal. A laparoscopic left adrenalectomy was performed. The postoperative course was uneventful, and no chemotherapy was administered. The pathological report confirmed an adrenal endometrioid metastasis. At 36 mo of follow-up, the patient is alive and well, with no evidence of recurrent disease. A literature review identified only 11 previously-published cases of adrenal metastases from uterine cancer.
CONCLUSION
Adrenal metastasis from uterine cancer is very rare. Laparoscopic adrenalectomy may be an effective treatment in selected cases of localized adrenal metastasis.
Core tip: Isolated adrenal metastasis from endometrial cancer is uncommon but should be suspected in patients with history of gynecological cancer. We report a case of large, metachronous adrenal metastasis from endometrial cancer successfully treated with laparoscopic resection. Mini-invasive surgery is safe and feasible with good oncological results also for metastatic lesions of adrenal gland.
