Yu YN, Yin XY, Sun Q, Liu H, Zhang Q, Chen YQ, Zhao QX, Tian ZB. Gastric adenocarcinoma of fundic gland type after Helicobacter pylori eradication: A case report. World J Clin Cases 2019; 7(13): 1696-1702 [PMID: 31367629 DOI: 10.12998/wjcc.v7.i13.1696]
Corresponding Author of This Article
Xiao-Yan Yin, MD, PhD, Chief Doctor, Department of Gastroenterology, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. yxy4503@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ya-Nan Yu, Xiao-Yan Yin, Hua Liu, Qi Zhang, Qing-Xi Zhao, Zi-Bin Tian, Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Qi Sun, Department of Pathology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Yun-Qing Chen, Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Yu YN and Yin XY wrote the manuscript; Sun Q and Chen YQ contributed to the immunohistochemistry and pathology; Liu H and Zhang Q contributed to the manuscript discussion; Zhao QX, Tian ZB, and Yin XY reviewed the manuscript.
Supported bythe National Natural Science Foundation of China, No. 81502025; and China Postdoctoral Science Foundation, No. 2018M632631.
Informed consent statement: Written informed consent from the patient was obtained.
Conflict-of-interest statement: Authors have no conflict of interest relevant to this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Yan Yin, MD, PhD, Chief Doctor, Department of Gastroenterology, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. yxy4503@163.com
Telephone: +86-532-82911303 Fax: +86-532-82911302
Received: March 25, 2019 Peer-review started: March 25, 2019 First decision: April 11, 2019 Revised: April 29, 2019 Accepted: May 10, 2019 Article in press: May 11, 2019 Published online: July 6, 2019 Processing time: 104 Days and 21.6 Hours
Abstract
BACKGROUND
Gastric adenocarcinoma of fundic gland type (GA-FG) has recently been proposed as a novel histological type of gastric cancer.
CASE SUMMARY
We report a case of GA-FG in a 77-year-old Chinese woman with epigastric distention who was referred to endoscopy for the management of an incidentally found submucosal tumor-like elevated lesion in the lower part of the gastric body. The tumor occurred after Helicobacter pylori (H. pylori) eradication therapy without long-term use of proton pump inhibitors. Complete and curable removal of the tumor was performed by endoscopic submucosal dissection. Histopathological findings showed numerous cells with basophilic cytoplasm and mildly atypical nuclei-like chief cells of the fundic gland. The tumor was observed to have the so-called “endless glands” pattern of the well-differentiated mixed phenotype. A safe resection margin without lymphatic and venous invasion was observed. As the tumor occurred after H. pylori eradication therapy, it is unknown whether there was a relationship with H. pylori eradication. The patient will be followed up by periodic gastroscopic observation.
CONCLUSION
In conclusion, we report a case of GA-FG after H. pylori eradication therapy without long-term proton pump inhibitors use. Further analysis of similar cases will reveal the clinical behavior of GA-FG.
Core tip: Gastric adenocarcinoma of fundic gland type (GA-FG) remains a rare disease despite a recent uptick in diagnoses. Here, we report a case of GA-FG with submucosal tumor-like appearance, located in the lower part of the gastric body. This case report discusses the probability-of-occurrence after Helicobacter pylori eradication therapy without long-term usage of proton pump inhibitors. Complete and curable removal of endoscopic submucosal dissection was performed. Further analysis of similar cases will reveal the clinical behavior of GA-FG.
