Zhang WQ, Bao Y, Qiu B, Wang Y, Li ZP, Wang YB. Clival metastasis of renal clear cell carcinoma: Case report and literature review. World J Clin Cases 2018; 6(9): 301-307 [PMID: 30211212 DOI: 10.12998/wjcc.v6.i9.301]
Corresponding Author of This Article
Yi-Bao Wang, MD, Professor, Department of Neurosurgery, First Affiliated Hospital of China Medical University, Floor # 18, Room # 1801, Shenyang 110001, Liaoning Province, China. cmuwyb@hotmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 6, 2018; 6(9): 301-307 Published online Sep 6, 2018. doi: 10.12998/wjcc.v6.i9.301
Clival metastasis of renal clear cell carcinoma: Case report and literature review
Wei-Qi Zhang, Yue Bao, Bo Qiu, Yong Wang, Zhi-Peng Li, Yi-Bao Wang
Wei-Qi Zhang, Yue Bao, Bo Qiu, Yong Wang, Zhi-Peng Li, Yi-Bao Wang, Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Zhang WQ and Bao Y examined the patient and collected clinical data; Wang YB and Wang Y performed surgical resection and follow up; Zhang WQ and Li ZP wrote the paper; Qiu B and Wang YB edited the manuscript and had final approval.
Institutional review board statement: The authors’ institution does not require IRB approval to publish a single case report.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi-Bao Wang, MD, Professor, Department of Neurosurgery, First Affiliated Hospital of China Medical University, Floor # 18, Room # 1801, Shenyang 110001, Liaoning Province, China. cmuwyb@hotmail.com
Telephone: +86-24-83283333 Fax: +86-24-83283333
Received: March 31, 2018 Peer-review started: April 2, 2018 First decision: May 24, 2018 Revised: June 1, 2018 Accepted: June 26, 2018 Article in press: June 27, 2018 Published online: September 6, 2018 Processing time: 159 Days and 18.7 Hours
Abstract
The clivus is an atypical metastatic site for renal clear cell carcinoma (RCCC). Here we report a 54 year old man with acute cavernous sinus syndrome. Brain magnetic resonance imaging identified a clival-based lesion with associated bony erosion. The patient underwent endoscopic endonasal biopsy and partial resection of the clival mass. Because histologic examination of the resected specimen resulted in a diagnosis of RCCC, contrast-enhanced computed tomography scan of the abdomen was performed and showed an enhanced left renal mass. The patient subsequently underwent laparoscopic left radical nephrectomy and gamma knife was planned for the residual clival lesion. We also retrospectively reviewed available published reports on clival metastases, specifically those from RCCC, since 1990.
Core tip: Clival metastasis is an extremely rare presentation of renal clear cell carcinoma. The symptom of sudden onset of cranial neuropathy, most commonly involving the abducens nerve, and findings on radiologic examination are crucial for making an early diagnosis. Histopathological diagnosis and resection of the clival mass can be safely achieved through an endoscopic endonasal approach. Multidisciplinary management, including surgery, stereotactic radiotherapy and tumor-targeted agents, is often required to prolong survival and maximize the quality of life for patients with metastatic renal cell carcinoma.
