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World J Clin Cases. Nov 26, 2018; 6(14): 745-752
Published online Nov 26, 2018. doi: 10.12998/wjcc.v6.i14.745
Necroptosis in inflammatory bowel disease and other intestinal diseases
Sha Li, Long-Gui Ning, Xin-He Lou, Guo-Qiang Xu
Sha Li, Long-Gui Ning, Xin-He Lou, Guo-Qiang Xu, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Li S contributed to the literature review and analysis, and prepared the manuscript; all authors contributed equally to the design, critical revision and editing, and approval of the final version for this paper.
Supported by Medical Science Research Foundation of Health Bureau of Zhejiang Province, No. WKJ-ZJ-1516.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guo-Qiang Xu, MD, Professor, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. 1193065@zju.edu.cn
Telephone: +86-571-87236718 Fax: +86-571-87236628
Received: August 17, 2018
Peer-review started: August 19, 2018
First decision: October 5, 2018
Revised: October 18, 2018
Accepted: October 31, 2018
Article in press: November 1, 2018
Published online: November 26, 2018
Processing time: 101 Days and 2.6 Hours
Abstract

For a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, inducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis of inflammatory bowel disease (IBD) and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD.

Keywords: Inflammatory bowel disease; Necroptosis; Inflammation; Colorectal cancer; Intestinal infectious diseases; Drug therapy; Receptor interacting protein kinase 1 inhibitor

Core tip: This minireview is based on the currently available literature about necroptosis and aims to uncover the role of necroptosis in the pathogenesis of inflammatory bowel disease and other intestinal diseases, including colorectal cancer and intestinal infectious diseases. The main regulatory pathways for necroptosis are summarized. Drug therapy targeting of necroptosis is also described.