Singh L, Singh A, Agarwal M, Mishra S. Is dengue emerging as important cause of acute liver failure in endemic regions? World J Clin Cases 2017; 5(7): 303-306 [PMID: 28798927 DOI: 10.12998/wjcc.v5.i7.303]
Corresponding Author of This Article
Dr. Lavleen Singh, Department of Pathology, Chacha Nehru Bal Chikitsalaya, Geeta Colony 110031, New Delhi, India. singhlavleen04@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Lavleen Singh, Amitabh Singh, Mitali Agarwal, Sataroopa Mishra, Department of Pathology, Chacha Nehru Bal Chikitsalaya, Geeta Colony 110031, New Delhi, India
Lavleen Singh, Amitabh Singh, Mitali Agarwal, Sataroopa Mishra, Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Geeta Colony 110031, New Delhi, India
Author contributions: Singh L and Singh A conceptualized the manuscript and reviewed it for intellectual content; Singh L, Singh A, Agarwal M and Mishra S wrote the manuscript and approved the final documents were involved in the clinical care of the patient.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Lavleen Singh, Department of Pathology, Chacha Nehru Bal Chikitsalaya, Geeta Colony 110031, New Delhi, India. singhlavleen04@gmail.com
Telephone: +91-901-3343819
Received: November 18, 2016 Peer-review started: November 20, 2016 First decision: December 29, 2016 Revised: January 4, 2017 Accepted: February 28, 2017 Article in press: March 2, 2017 Published online: July 16, 2017
Abstract
Dengue virus infection continues to be major public health problem in large part of world. The epidemiology of dengue viral infection is becoming increasingly complex and has substantially changed over almost past six decades not only in terms of prevalent strains and geographical locations but also in terms of disease severity and atypical presentations. Though liver is the most common organ affected but is generally asymptomatic. We present a case of infant with severe dengue who died of fulminant hepatic failure and showed pan lobular necrosis on post mortem liver biopsy. The case is being presented to highlight life threatening complication of dengue in young children, and dengue viral infection as a cause of acute liver failure in endemic areas. Thus dengue fever should also be considered as one of the differential diagnosis in children presenting with fever and fulminant hepatic failure in endemic regions.
Core tip: Dengue infection has more severe manifestation in young children and it should be considered as a cause of acute liver failure in children residing in endemic area.
