Published online Apr 16, 2017. doi: 10.12998/wjcc.v5.i4.134
Peer-review started: November 9, 2016
First decision: November 30, 2016
Revised: January 8, 2017
Accepted: January 16, 2017
Article in press: January 18, 2017
Published online: April 16, 2017
To determine the prevalence of esophageal squamous papillomas (ESPs) in a tertiary teaching hospital and to assess for any clinical associations, including relations with esophageal squamous cell carcinomas (SCCs).
Data from a total of 6962 upper gastrointestinal endoscopies over a five year period were retrospectively obtained and analysed.
ESP was found in sixteen patients (0.23%). Eight (50%) patients had a high body mass index, seven (44%) had history of cigarette smoking. Reflux esophagitis was found in four (25%) patients. All ESPs were solitary with a mean endoscopic size of 3.8 mm and located in the mid to lower esophagus. Human papilloma virus (HPV) was tested in three (19%) patients and was negative. Esophageal SCC was found in seven patients (0.10%) during the same period. None of the specimens were tested for HPV, and none had associated papillomatous changes.
ESP is an uncommon tumour with unclear clinical associations and malignant potential.
Core tip: Esophageal squamous papilloma is a rare endoscopic finding with uncertain clinicopathological associations. They are usually asymptomatic and their aetiology is unknown. A high body mass index and a history of cigarette smoking, both risk factors for gastroesophageal reflux disease, were the most prevalent patient characteristic in our cohort with esophageal squamous papillomas (ESPs), however no definite associations can be established. None of the esophageal squamous cell carcinomas during the same study period progressed from ESP. Long-term longitudinal studies would be valuable to clarify clinical associations and the malignant potential of ESPs in order to establish appropriate management and surveillance strategies.