Eroglu E, Kocyigit I, Unal A, Sipahioglu MH, Akgun H, Kaynar L, Tokgoz B, Oymak O. Unicentric Castleman’s disease associated with end stage renal disease caused by amyloidosis. World J Clin Cases 2017; 5(3): 119-123 [PMID: 28352636 DOI: 10.12998/wjcc.v5.i3.119]
Corresponding Author of This Article
Eray Eroglu, MD, Department of Internal Medicine, Erciyes University School of Medicine, Köşk, Talas Blv., 38039 Kayseri, Turkey. drerayeroglu@hotmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Eray Eroglu, Ismail Kocyigit, Aydin Unal, Murat Hayri Sipahioglu, Bulent Tokgoz, Oktay Oymak, Division of Nephrology, Department of Internal Medicine, Erciyes University School of Medicine, 38039 Kayseri, Turkey
Hulya Akgun, Department of Pathology, Erciyes University School of Medicine, 38039 Kayseri, Turkey
Leylagul Kaynar, Division of Hematology, Department of Internal Medicine, Erciyes University School of Medicine, 38039 Kayseri, Turkey
Author contributions: Eroglu E and Oymak O designed the report; Unal A and Sipahioglu MH performed the kidney biopsy; Eroglu E and Kaynar L collected the patient’s clinical data; Akgun H reported the biopsy specimens; Eroglu E and Kocyigit I analyzed the data and wrote the paper; all the authors contributed to this article.
Institutional review board statement: Not applicable due to the case report format.
Informed consent statement: Informed consent was obtained from the patient included in the case report.
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eray Eroglu, MD, Department of Internal Medicine, Erciyes University School of Medicine, Köşk, Talas Blv., 38039 Kayseri, Turkey. drerayeroglu@hotmail.com
Telephone: +90-530-9220517 Fax: +90-352-4375807
Received: October 9, 2016 Peer-review started: October 13, 2016 First decision: November 11, 2016 Revised: November 29, 2016 Accepted: January 16, 2017 Article in press: January 18, 2017 Published online: March 16, 2017 Processing time: 155 Days and 9.3 Hours
Abstract
Castleman’s disease (CD), also known as angiofolicular lymph node hyperplasia, is a rare heterogenous group of lymphoproliferative disorders. Histologically, it can be classified as hyaline vascular type, plasma cell type, or mixed type. Clinically two different subtypes of the CD are present: Unicentric and multicentric. Unicentric CD is generally asymptomatic and associated with hyaline vascular type, and its diagnoses depend on the localized lymphadenopathy on examination or imaging studies. However, multicentric CD presents with generalized lymphadenopathy and systemic symptoms including malaise, fever, night sweats, weight loss, and it is associated with the plasma cell type and mix type. Herein, we report a patient with unicentric CD of the plasma cell type without systemic symptoms, who developed end stage renal failure caused by amyloidosis 6 years after onset of CD.
Core tip: Castleman’s disease (CD), also known as angiofolicular lymph node hyperplasia, is a heterogeneous group of lymphoproliferative disorders. The clinically unicentric form is generally asymptomatic and often associated with hyaline vascular type. The unicentric form of the disease often shows mild to moderate clinical prognosis, however the multicentric form is a more severe form. After the complete surgical removal of the lymph node, remission is achieved in many cases and complications are very rare. However, this case of unicentric CD of the plasma cell type is unique due to the fact that it presented with amyloidosis and end stage renal disease six years after the onset of the disease.
