Case Report
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World Journal of Clinical Cases. Nov 16, 2017; 5(11): 403-406
Published online Nov 16, 2017. doi: 10.12998/wjcc.v5.i11.403
Acid suppressive therapy improved symptoms due to circumferential cervical inlet patch with proton pumps (H+/K+-ATPase)
Takanori Yamada, Atsushi Tsuji, Shunya Onoue, Masanao Kaneko, Fumihiko Tanioka, Satoshi Osawa, Yasuhiko Saida
Takanori Yamada, Atsushi Tsuji, Shunya Onoue, Masanao Kaneko, Yasuhiko Saida, Department of Gastroenterology, Iwata City Hospital, Iwata 438-8550, Japan
Fumihiko Tanioka, Division of Pathology, Iwata City Hospital, Iwata 438-8550, Japan
Satoshi Osawa, Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Author contributions: Yamada T wrote the paper; Tsuji A treated the patient and performed endoscopy; Onoue S, Kaneko M, Osawa S and Saida Y contributed to the paper design and coordination; Tanioka F contributed to the pathological examination.
Institutional review board statement: This case report was exempt from the Institutional Review Board Standards at Iwata City Hospital, Iwata, Japan.
Informed consent statement: The patient has provided permission to publish this paper, and the identity of the patient has been protected.
Conflict-of-interest statement: No conflict interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Takanori Yamada, MD, PhD, Department of Gastroenterology, Iwata City Hospital, 512-3 Okubo, Iwata 438-8550, Japan.
Telephone: +81-538-385000 Fax: +81-538-385050
Received: July 26, 2017
Peer-review started: July 26, 2017
First decision: August 16, 2017
Revised: August 25, 2017
Accepted: September 12, 2017
Article in press: September 13, 2017
Published online: November 16, 2017

Cervical inlet patch (CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of CIP. Herein, we present a 55-year-old man with symptomatic circumferential inlet patch. He exhibited globus and dysphagia, and esophagogastroduodenoscopy found cir-cumferential CIP, where im-munohistochemistry revealed the existence of pro-ton pumps (H+, K+-ATPase). His throat symptoms were relieved by acid suppressive therapy with pump inhibitors. This case indicated that CIP should be considered as a differential diagnosis for the cause of globus symptoms in rare cases.

Keywords: Cervical inlet patch, Proton pump inhibitor

Core tip: Cervical inlet patch (CIP) is the esophageal heterotopic gastric mucosa in the cervical esophagus. We present a 55-year-old man exhibiting circumferential CIP with globus and dysphagia. Proton pump inhibitors relived these throat symptoms. Immunohistochemistry revealed existence of proton pumps in the CIP lesion. The throat symptoms were suggested to be related with CIP and acid secretion.