Meena US, Sharma S, Chopra S, Jain SK. Gliosarcoma: A rare variant of glioblastoma multiforme in paediatric patient: Case report and review of literature. World J Clinical Cases 2016; 4(9): 302-305 [PMID: 27672648 DOI: 10.12998/wjcc.v4.i9.302]
Corresponding Author of This Article
Dr. Ugan Singh Meena, Mch, Senior Registrar (Neurosurgery), Department of Neurosurgery, Swai Man Singh Medical College, Jaipur, Rajasthan 302004, India. uganmamc@gmail.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ugan Singh Meena, Sumit Sharma, Sanjeev Chopra, Shashi Kant Jain, Department of Neurosurgery, Swai Man Singh Medical College, Rajasthan 302004, India
Author contributions: Meena US invoved in majority of work including concept, design, literature search, clinical studies, manuscript preparation, manuscript editing; Sharma S helps in data collection and manuscript preparation; Chopra S helps in manuscript editing; Jain SK helps in manuscript editing and reviewing.
Institutional review board statement: Not available.
Informed consent statement: Not available.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Ugan Singh Meena, Mch, Senior Registrar (Neurosurgery), Department of Neurosurgery, Swai Man Singh Medical College, Jaipur, Rajasthan 302004, India. uganmamc@gmail.com
Telephone: +91-0141-2518801
Received: January 23, 2016 Peer-review started: January 24, 2016 First decision: April 18, 2016 Revised: May 8, 2016 Accepted: July 14, 2016 Article in press: July 16, 2016 Published online: September 16, 2016 Processing time: 228 Days and 19 Hours
Abstract
Gliosarcoma is rare central nervous system tumour and a variant of glioblastoma multiforme with bimorphic histological pattern of glial and sarcomatous differentiation. It occurs in elderly between 5th and 6th decades of life and extremely rare in children. It is highly aggressive tumour and managed like glioblastoma multiforme. A 12-year-old female child presented with complaints of headache and vomiting from 15 d and blurring of vision from 3 d. Magnetic resonance imaging of brain shows heterogeneous mass in right parieto-occipital cortex. A right parieto-occipito-temporal craniotomy with complete excision of mass revealed a primary glioblastoma on histopathological investigation. Treatment consists of maximum surgical excision followed by adjuvant radiotherapy. The etiopathogenesis, treatment modalities and prognosis is discussed. The available literature is also reviewed.
Core tip: We report a rare case of primary gliosarcoma right parieto-occipital cortex in a 12-year-old girl with review of available literature. The etiopathogenesis, treatment modalities and prognosis is discussed in view of the literature.
