Published online Nov 16, 2016. doi: 10.12998/wjcc.v4.i11.356
Peer-review started: March 10, 2016
First decision: May 19, 2016
Revised: August 24, 2016
Accepted: September 13, 2016
Article in press: September 18, 2016
Published online: November 16, 2016
To elucidate the profile of the salivary proteome.
Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia (PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach, followed by analyses of variance and logistic regression tests.
A total of two hundred and eighty-three proteins were confidently identified in saliva. By combining two low abundance proteins from the PVL group, angiotensinogen (AGT) and dipeptidyl peptidase 1 (DPP1), a model for group differentiation was built with a concordance index of 94.2%, identifying both proteins as potential etiologic biomarkers for PVL.
This study suggests that both AGT and DPP1 may be involved in developmental mechanisms of PVL.
Core tip: Saliva is a useful source for analysis of proteins that can be associated in many diseases, including proliferative verrucous leukoplakia (PVL). This study showed that angiotensinogen and dipeptidyl peptidase 1 may be important in PVL development.