Published online Oct 16, 2016. doi: 10.12998/wjcc.v4.i10.351
Peer-review started: May 3, 2016
First decision: June 17, 2016
Revised: July 11, 2016
Accepted: July 20, 2016
Article in press: July 22, 2016
Published online: October 16, 2016
The combination of kidney paired donation (KPD) with desensitization represents a promising method of increasing the rate of living donor kidney transplantation (LDKT) in immunologically challenging patients. Patients who are difficult to match and desensitize due to strong donor specific antibody are may be transplanted by a combination of desensitization and KPD protocol with more immunologically favorable donor. We present our experience of combination of desensitization protocol with three-way KPD which contributed to successful LDKT in highly sensitized end stage renal disease patient. All recipients were discharged with normal and stable allograft function at 24 mo follow up. We believe that this is first report from India where three-way KPD exchange was performed with the combination of KPD and desensitization. The combination of desensitization protocol with KPD improves access and outcomes of LDKT.
Core tip: The combination of desensitization protocol with kidney paired donation (KPD) improves access and outcomes of living donor kidney transplantation, minimizing the limitation of either desensitization protocol or KPD alone. This is useful for sensitized patients who are both difficult to match and desensitize due to panel reactive antigens and strong donor specific antibody.