Kulkarni RV, Ingle SB, Siddiqui S. Primary signet ring cell carcinoma of the appendix: A rare case report. World J Clin Cases 2015; 3(6): 538-541 [PMID: 26090376 DOI: 10.12998/wjcc.v3.i6.538]
Corresponding Author of This Article
Sachin B Ingle, Professor, Department of Pathology, MIMSR Medical College, Ambajogai Road, vishwanathpuram, Maharashtra 4132512, India. dr.sachiningle@gmail.com
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 16, 2015; 3(6): 538-541 Published online Jun 16, 2015. doi: 10.12998/wjcc.v3.i6.538
Primary signet ring cell carcinoma of the appendix: A rare case report
Ram V Kulkarni, Sachin B Ingle, Saleha Siddiqui
Ram V Kulkarni, Sachin B Ingle, Saleha Siddiqui, Department of Pathology, MIMSR Medical College, Latur, Maharashtra 4132512, India
Author contributions: Kulkarni RV and Siddiqui S prepared the manuscript; Ingle SB critically revised the intellectual content and gave final approval of manuscript.
Ethics approval: The work done and contributions of all authors is original and ethical. The review board appreciates their work and permits them to publish their work in indexed medical journal for global readers.
Conflict-of-interest: None to be declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sachin B Ingle, Professor, Department of Pathology, MIMSR Medical College, Ambajogai Road, vishwanathpuram, Maharashtra 4132512, India. dr.sachiningle@gmail.com
Telephone: +91-2382-227424 Fax: +91-2382-228939
Received: October 26, 2014 Peer-review started: October 27, 2014 First decision: January 20, 2015 Revised: February 3, 2015 Accepted: March 16, 2015 Article in press: March 18, 2015 Published online: June 16, 2015
Abstract
Primary adenocarcinoma of the appendix is a rare malignancythat constitutes < 0.5% of all gastrointestinalneoplasms. Moreover, primary signet ring cell carcinomaof the appendix is an exceedingly rare entity. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastasesand unresectable peritoneal dissemination occurring in a 45-year-old female patient. She was clinically misdiagnosed as torsion of ovarian cyst. She underwent appendicectomy and unilateral salpingo-oophorectomy.Histopathology revealed signet ring cell carcinoma and a right hemicolectomy was done. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX-4). The patient is doing well till today on follow up without progression of disease 10 mo after beginning chemotherapy.
Core tip: Meticulous histopathological evaluation along with clinical correlation is strongly recommended in such unusual circumstances. The clinician and surgical pathologist should keep in mind this rare entity as a differential diagnosis.
