Cetinkunar S, Erdem H, Aktimur R, Sozen S. Effect of bariatric surgery on humoral control of metabolic derangements in obese patients with type 2 diabetes mellitus: How it works. World J Clin Cases 2015; 3(6): 504-509 [PMID: 26090370 DOI: 10.12998/wjcc.v3.i6.504]
Corresponding Author of This Article
Suleyman Cetinkunar, MD, Clinic of General Surgery, Adana Numune Training and Research Hospital, Serinevler mh Ege Bagatur Blv., 01240 Yuregir, Adana, Turkey. slmcetin@gmail.com
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 16, 2015; 3(6): 504-509 Published online Jun 16, 2015. doi: 10.12998/wjcc.v3.i6.504
Effect of bariatric surgery on humoral control of metabolic derangements in obese patients with type 2 diabetes mellitus: How it works
Suleyman Cetinkunar, Hasan Erdem, Recep Aktimur, Selim Sozen
Suleyman Cetinkunar, Hasan Erdem, Clinic of General Surgery, Adana Numune Training and Research Hospital, 01240 Yuregir, Adana, Turkey
Recep Aktimur, Clinic of General Surgery, Samsun Training and Research Hospital, Ilkadım, 55100 Samsun, Turkey
Selim Sozen, Department of General Surgery, Faculty of Medicine, Namık Kemal University, 59100 Merkez, Tekirdag, Turkey
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest: The authors declare that there is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Suleyman Cetinkunar, MD, Clinic of General Surgery, Adana Numune Training and Research Hospital, Serinevler mh Ege Bagatur Blv., 01240 Yuregir, Adana, Turkey. slmcetin@gmail.com
Telephone: +90-505-4133397
Received: December 26, 2014 Peer-review started: December 29, 2014 First decision: January 20, 2015 Revised: March 13, 2015 Accepted: April 10, 2015 Article in press: April 14, 2015 Published online: June 16, 2015 Processing time: 175 Days and 11.8 Hours
Abstract
Obesity and diabetes is a co-pandemic and a major health concern that is expanding. It has many psychosocial and economic consequences due to morbidity and mortality of this disease combination. The pathophysiology of obesity and related diabetes is complex and multifactorial. One arm of this disease process is the genetic susceptibility. Other arm is dependent on the intricate neuro-humoral factors that converge in the central nerve system. Gut hormones and the adipose tissue derived factors plays an important role in this delicate network. Bariatric surgery provides the only durable option for treatment of obesity and furthermore it provides a remission in the concomitant diseases that accompany obesity. This review provides a brief insight to all these mechanisms and tries to deduce the possible reasons of remission of type 2 diabetes after bariatric surgery.
