Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2015; 3(12): 988-992
Published online Dec 16, 2015. doi: 10.12998/wjcc.v3.i12.988
Sarcoma-associated sarcoid reaction: Report of cutaneous sarcoid reaction in a patient with liposarcoma
Bryce D Beutler, Philip R Cohen
Bryce D Beutler, School of Allied Health Sciences, University of Nevada, Las Vegas, NV 89154, United States
Philip R Cohen, Department of Dermatology, University of California, San Diego, CA 92093, United States
Author contributions: All authors contributed to the acquisition of data, writing, and revision of this manuscript.
Institutional review board statement: This case report was exempt from the Institutional Review Board standards.
Informed consent statement: The patient involved in this study gave his written informed consent authorizing use and disclosure of his protected health information.
Conflict-of-interest statement: All of the authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bryce D Beutler, BS, School of Allied Health Sciences, University of Nevada, 4505 S. Maryland Pkwy, Las Vegas, NV 89154, United States. mitehead@gmail.com
Telephone: +1-760-2718901 Fax: +1-509-3529699
Received: May 18, 2015
Peer-review started: May 19, 2015
First decision: June 18, 2015
Revised: September 21, 2015
Accepted: October 1, 2015
Article in press: October 8, 2015
Published online: December 16, 2015
Processing time: 204 Days and 5.7 Hours
Abstract

Sarcoidosis is a systemic inflammatory condition in which noncaseating epithelioid cell granulomas appear within one or several body sites. Sarcoid reaction (also referred to as sarcoidal or sarcoid-like reaction) occurs in patients who do not fulfill the diagnostic criteria for systemic sarcoidosis but present with similar clinical and histological features. As sarcoma-associated sarcoid reactions are rare, we describe the features of sarcoid reaction that developed in a man with liposarcoma and summarize reports of other oncology patients with sarcoma-associated sarcoid reactions. A 68-year-old man with retroperitoneal liposarcoma presented for evaluation of erythematous dermal plaques on his left leg. Microscopic examination of a tissue specimen revealed multiple epithelioid granulomas in the superficial and mid-reticular dermis. Correlation of the clinical presentation and histopathologic findings established a diagnosis of liposarcoma-associated cutaneous sarcoid reaction. Sarcoid reactions have been described in only seven individuals with sarcoma, including two patients with leiomyosarcoma and one patient with either carcinosarcoma, Kaposi sarcoma, liposarcoma, malignant peripheral nerve sheath tumor, rhabdosarcoma, or synovial sarcoma. Sarcoidal granulomas most commonly develop within the locoregional draining lymph nodes. Sarcoid reactions may also affect other organs, such as the lungs, skin, and spleen.

Keywords: Liposarcoma; Malignancy; Sarcoid; Sarcoid reaction; Sarcoidosis; Sarcoma

Core tip: Sarcoid reaction is an inflammatory condition in which noncaseating epithelioid cell granulomas develop within one or several body sites. Several malignancies, including lymphomas and carcinomas, have been linked to sarcoid reaction. We describe the first case of a patient presenting with liposarcoma-associated sarcoid reaction and summarize the literature on rare patients with sarcoma-associated sarcoid reactions. It is imperative that clinicians consider sarcoid reaction in the evaluation of oncology patients prior to initiating treatment.