Published online Sep 16, 2014. doi: 10.12998/wjcc.v2.i9.478
Revised: June 10, 2014
Accepted: June 27, 2014
Published online: September 16, 2014
As per strict criteria of Das Gupta et al, primary splenic lymphoma is very rare. Herein, we are reporting an unusual case of primary large cell splenic lymphoma of B lineage in a middle aged female presenting with massive splenomegaly (3.8 kg) and hypersplenism. After performing therapeutic splenectomy for hypersplenism, a precise diagnosis of diffuse large B cell lymphoma was made on histopathology and confirmed by immunohistochemistry. The patient responded well to standard (Cyclophosphamide, Hydroxydaunorubicin, Oncovin (vincristine), Prednisone or prednisolone) regimen last year and is now in full remission. The splenectomy thereby has prevented the potential grave complications related to hypersplenism and splenic rupture. Our aim behind highlighting the topic is to specify that emergency splenectomy followed by anticoagulation therapy is an effective plan of management to prevent untoward complications related to disease and treatment.
Core tip: Primary splenic lymphoma is a rare entity, can present with grave complications like hypersplenism and splenic rupture. In such circumstances, emergency splenectomy is an effective therapeutic and diagnostic tool. Now a days laparoscopic splenectomy is emerging because of minimal complications. Postoperative anticoagulation is important to prevent portal splenic vein thrombosis.