Editorial
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2014; 2(11): 608-613
Published online Nov 16, 2014. doi: 10.12998/wjcc.v2.i11.608
Important of case-reports/series, in rare diseases: Using neuroendocrine tumors as an example
Taichi Nakamura, Hisato Igarashi, Tetsuhide Ito, Robert T Jensen
Taichi Nakamura, Robert T Jensen, Cell Biology Section, NIDDK, National Institutes of Health, Bethesda, Maryland, MD 20814, United States
Hisato Igarashi, Tetsuhide Ito, Department of Medicine and Bioregulatory Science, Kyushu University, Fukuoka 812-8581, Japan
Author contributions: All authors contributed to all phases of the paper including the formulation of the ideas, writing, literature research and proofing the final paper.
Supported by Intramural Research Funds of NIDDK, NIH
Correspondence to: Dr. Robert T Jensen, Cell Biology Section, NIDDK, National Institutes of Health, 10 Center Dr., Bldg. 10, Room 9C103, Bethesda, Maryland, MD 20814, United States. robertj@bdg10.niddk.nih.gov
Telephone: +1-301-4964201 Fax: +1-301-4020600
Received: June 30, 2014
Revised: September 3, 2014
Accepted: September 16, 2014
Published online: November 16, 2014
Abstract

At present the publishing of case reports or case series involving small numbers of cases is controversial. While in the past they were commonly published by most journals, recently a number of prominent journals have either stopped publishing them or markedly reduced the numbers published. However, recently an increasing case is being made for their value and a number of new journals have been started devoted specifically to their publication. One of the arguments used for their value is their prominent role in rare diseases either in their recognition, full description or development of treatments. However this aspect has not been specifically studied. In this editorial this aspect is specifically examined using their role in neuroendocrine tumors as an example. Furthermore, the background of the controversy is briefly reviewed to better understand the context of this editorial.

Keywords: Case report, Case series, Neuroendocrine tumors, Carcinoids, Pancreatic neuroendocrine tumor

Core tip: A review of neuroendocrine tumors, which are rare diseases, strongly supports the prominent role and value of reporting of rare cases or small case series in uncommon disorders.