Zheng ZH, Shao B, Xu CM, Wang K, Wen JZ, Luo LK, Guan JC. Primary parenchymal squamous cell carcinoma of the kidney: A case report. World J Clin Cases 2025; 13(4): 100037 [DOI: 10.12998/wjcc.v13.i4.100037]
Corresponding Author of This Article
Jia-Cheng Guan, Doctor, Associate Chief Physician, Department of Radiology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Qujiang District, Quzhou 324000, Zhejiang Province, China. gjcqzey@126.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2025; 13(4): 100037 Published online Feb 6, 2025. doi: 10.12998/wjcc.v13.i4.100037
Primary parenchymal squamous cell carcinoma of the kidney: A case report
Zhi-Hui Zheng, Bo Shao, Chao-Min Xu, Ke Wang, Jia-Zhu Wen, Li-Kang Luo, Jia-Cheng Guan
Zhi-Hui Zheng, Chao-Min Xu, Department of Ultrasound, The Second People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
Bo Shao, Department of Radiology, Shulan (Quzhou) Hospital, Quzhou 324000, Zhejiang Province, China
Ke Wang, Jia-Zhu Wen, Jia-Cheng Guan, Department of Radiology, The Second People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
Li-Kang Luo, Department of Pathology, The Second people’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
Co-first authors: Zhi-Hui Zheng and Bo Shao.
Author contributions: Zheng ZH and Shao B designed the study, prepared and drafted the manuscript; Xu CM proofread the manuscript; Wen JZ and Luo LK contributed to the acquisition of imaging data; Wang K interpreted the findings; Guan JC provided critical manuscript revision for important intellectual content; All authors have read and approve the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Cheng Guan, Doctor, Associate Chief Physician, Department of Radiology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Qujiang District, Quzhou 324000, Zhejiang Province, China. gjcqzey@126.com
Received: August 5, 2024 Revised: September 27, 2024 Accepted: October 29, 2024 Published online: February 6, 2025 Processing time: 101 Days and 8.4 Hours
Abstract
BACKGROUND
Primary squamous cell carcinoma (SCC) of the renal parenchyma is extremely rare, with only nine cases reported.
CASE SUMMARY
This study reports a 51-year-old man with primary SCC of the renal parenchyma. The patient was admitted with recurrent dull pain and discomfort in the right lumbar region, which had worsened over 2 weeks, accompanied by painful gross hematuria. SCC antigen (SCCA) levels were elevated, and imaging revealed a renal mass with associated calculi. The patient underwent laparoscopic unilateral nephrectomy and lymph node dissection. Postoperative pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma, with negative renal pelvis and ureter. The pathological stage was Pt3aN1M0. Four months after surgery, the tumor recurred with involvement of the liver, right psoas major muscle, and inferior vena cava. The patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease progression.
CONCLUSION
We report a case of primary SCC of the renal parenchyma, a rare renal malignancy. The clinical symptoms, laboratory tests, and imaging findings are nonspecific, making accurate and timely diagnosis challenging. According to the literature, for patients with renal calculi accompanied by a renal mass, elevated serum SCCA levels, and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement, the possibility of this disease should be considered.
Core Tip: Primary squamous cell carcinoma (SCC) of the renal parenchyma is extremely rare. This study reports a 51-year-old man with primary SCC of the renal parenchyma, accompanied by lymph node metastasis. A comprehensive exposition of its clinical trajectory and imaging manifestation is presented, aiming to enhance comprehension and management of this rare disease.
