Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2025; 13(29): 108411
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.108411
Low salivary uric acid levels and periodontitis: New insights and implications for clinical practice
Zhuo-Qun Hu, Yong Wang
Zhuo-Qun Hu, Department of Stomatology, Yanbian University Hospital, Yanji 133000, Jilin Province, China
Yong Wang, Department of Internal Medicine, Yanbian University Hospital, Yanji 133000, Jilin Province, China
Author contributions: Wang Y contributed to conception and design; Hu ZQ contributed to literature search and writing; All of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Wang, Researcher, Yanbian University Hospital, No. 1327 Ju Zi Road, Yanji 133000, Jilin Province, China. wangyong0327ybu@163.com
Received: April 14, 2025
Revised: May 23, 2025
Accepted: July 22, 2025
Published online: October 16, 2025
Processing time: 137 Days and 3.1 Hours
Abstract

In this letter, we delve into the groundbreaking research by Lorente et al, which sheds light on the intricate relationship between low salivary uric acid levels and periodontitis. The study not only confirms previous observations of reduced salivary uric acid concentrations in periodontitis patients but also establishes, for the first time, an independent association between these two factors, even when controlling for traditional risk factors such as age, smoking status, and arterial hypertension. Moreover, the findings reveal a significant negative correlation between salivary uric acid levels and the severity of periodontitis, suggesting that this biomarker may serve as a valuable indicator of disease progression. These discoveries open new avenues for understanding the pathophysiology of periodontitis and pave the way for innovative diagnostic and therapeutic strategies. The potential clinical applications of salivary uric acid measurement, such as guiding personalized treatment plans and monitoring disease activity, warrant further exploration to enhance patient care and improve outcomes in this prevalent inflammatory condition.

Keywords: Clinical practice; Biomarker; Oxidative stress; Periodontitis; Salivary uric acid

Core Tip: This letter explores the relationship between low salivary uric acid levels and periodontitis, revealing a significant independent association and inverse correlation with disease severity. Salivary uric acid emerges as a potential biomarker for disease progression, offering new insights into the pathophysiology of periodontitis and paving the way for innovative diagnostic and therapeutic strategies in clinical practice.