Nagoba BS, Dhotre SV, Gavkare AM, Mumbre SS, Dhotre PS. Cutaneous nocardiosis in chronic renal insufficiency: Diagnostic and therapeutic considerations. World J Clin Cases 2025; 13(26): 108211 [DOI: 10.12998/wjcc.v13.i26.108211]
Corresponding Author of This Article
Basavraj S Nagoba, PhD, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 16, 2025; 13(26): 108211 Published online Sep 16, 2025. doi: 10.12998/wjcc.v13.i26.108211
Cutaneous nocardiosis in chronic renal insufficiency: Diagnostic and therapeutic considerations
Basavraj S Nagoba, Shree V Dhotre, Ajay M Gavkare, Sachin S Mumbre, Pradnya S Dhotre
Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India
Shree V Dhotre, Department of Microbiology, Ashwini Rural Medical College, Solapur 413006, Maharashtra, India
Ajay M Gavkare, Department of Physiology, Maharashtra Institute of Medical Sciences & Research (Medical College), Latur 413531, Maharashtra, India
Sachin S Mumbre, Department of Community Medicine, Ashwini Rural Medical College, Solapur 413006, India
Pradnya S Dhotre, Department of Biochemistry, Ashwini Rural Medical College, Solapur 413006, India
Co-first authors: Basavraj S Nagoba and Shree V Dhotre.
Author contributions: Nagoba BS and Dhotre SV designed the overall concept and outline of the manuscript; Gavkare AM, Mumbre SS, and Dhotre PS contributed to the discussion and design of the manuscript; Nagoba BS, Dhotre SV and Gavkare AM contributed to the writing, and editing the manuscript and review of literature; all of the authors read and approved the final version of the manuscript to be published. Nagoba BS and Dhotre SV contributed equally to this work as co-first authors.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Basavraj S Nagoba, PhD, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com
Received: April 8, 2025 Revised: April 24, 2025 Accepted: June 13, 2025 Published online: September 16, 2025 Processing time: 106 Days and 21.6 Hours
Abstract
Nocardiosis remains a rare and often underdiagnosed bacterial infection, particularly in immunocompromised individuals. The case report by Zhang et al highlights the diagnostic and therapeutic challenges in managing Nocardia brasiliensis skin infection in a 93-year-old patient with chronic renal insufficiency. This editorial explores the importance of timely diagnosis, microbiological confirmation, and tailored antibiotic therapy. Emphasis is placed on the role of immune status evaluation, drug concentration monitoring, and the necessity of long-term antimicrobial therapy. Improved clinician awareness and adherence to evidence-based management protocols are essential to achieving better outcomes in nocardiosis cases.
Core Tip: This editorial unravels the diagnostic and therapeutic challenges of nocardiosis in immunocompromised patients. It emphasizes the power of microbiological precision, tailored antibiotic regimens, and immune status assessment. A compelling case of Nocardia brasiliensis in chronic renal insufficiency offers key takeaways for clinicians tackling similar hurdles.
