Abed M, Bradley A, Ghazanfar A. Use of OviTex 1S, reinforced tissue matrix, for the repair of post renal transplant incisional hernias: Four case reports. World J Clin Cases 2025; 13(18): 99749 [DOI: 10.12998/wjcc.v13.i18.99749]
Corresponding Author of This Article
Abbas Ghazanfar, Renal and Transplant Unit, St Georges University Hospitals NHS Foundation Trust, Blackshaw Road, Tooting, London SW17 0QT, United Kingdom. a.ghazanfar@nhs.net
Research Domain of This Article
Transplantation
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2025; 13(18): 99749 Published online Jun 26, 2025. doi: 10.12998/wjcc.v13.i18.99749
Use of OviTex 1S, reinforced tissue matrix, for the repair of post renal transplant incisional hernias: Four case reports
Mariam Abed, Angus Bradley, Abbas Ghazanfar
Mariam Abed, Angus Bradley, Department of Renal Transplantation, St George's University Hospital, London SW17 0QT, United Kingdom
Abbas Ghazanfar, Renal and Transplant Unit, St Georges University Hospitals NHS Foundation Trust, London SW17 0QT, United Kingdom
Co-first authors: Mariam Abed and Angus Bradley.
Author contributions: Abed M was responsible for data collection, data analysis and wrote the paper; Bradley A was responsible for data analysis, wrote the paper; Ghazanfar A conceived and designed the analysis, contributed data or analysis tools, and advisor; Abed M and Bradley A contribute equally to this study as co-first authors.
Informed consent statement: Patient details kept confidential with no identifiable information used.
Conflict-of-interest statement: The authors have nothing to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abbas Ghazanfar, Renal and Transplant Unit, St Georges University Hospitals NHS Foundation Trust, Blackshaw Road, Tooting, London SW17 0QT, United Kingdom. a.ghazanfar@nhs.net
Received: July 29, 2024 Revised: November 5, 2024 Accepted: February 14, 2025 Published online: June 26, 2025 Processing time: 212 Days and 19.9 Hours
Abstract
BACKGROUND
Incisional hernia is one of the known complications of renal transplant surgery, with a reported incidence between 1.1% to 3.8%. Depending on the site and extent of incisional hernia, it may require surgery particularly if it contains the transplanted kidney either partially or completely. The current common clinical practice is to repair incisional hernias using polypropylene meshes, which have their own risks and benefits. Biological meshes, which are made from human or animal-derived connective tissue, are also in use and have a less inflammatory response. Recently, hybrid meshes have been developed. These are composed of both biological and synthetic products. One such example is OviTex 1S permanent, which is a sterile reinforced tissue matrix composed of ovine (sheep) derived extracellular matrix and monofilament polypropylene. In this case report, we are sharing our experience with the use of OviTex 1S in the repair of post-renal transplant incisional hernias.
CASE SUMMARY
We report four cases of post-renal transplant incisional hernia with a median time of 27 months post-surgery. The median size of the defect was 15 cm long. There was no post-operative complication. One patient required renal transplant biopsy after mesh repair, which was easily performed compared with polypropylene meshes repaired hernias in the past.
CONCLUSION
The OviTex 1S mesh provides benefits in hernial repairs pKTx, but cost is an issue, and their long-term viability is unclear. Continued use and reporting will help build a more informed picture.
Core Tip: An incisional hernia is one of the known complications of renal transplant surgery and, depending on the site and extent of the hernia, may require surgery. The repair of incisional hernias post kidney transplantation (pRTx) has traditionally used synthetic mesh. However, they are associated with complications. Hybrid meshes, such as OviTex 1S, are a new type of mesh combining both synthetic and biological mesh properties in an attempt to improve post-operative outcomes. This case series reports 4 cases where OviTex 1S permanent mesh is used in the repair of pRTx incisional hernias.
