Wu ZW, Zhu WJ, Huang S, Tan Q, You C, Hu DG, Li LN. Eccrine porocarcinoma in the tempus of an elderly woman: A case report. World J Clin Cases 2024; 12(8): 1523-1529 [PMID: 38576807 DOI: 10.12998/wjcc.v12.i8.1523]
Corresponding Author of This Article
Long-Nian Li, PhD, Associate Chief Physician, Department of Dermatology, First Affiliated Hospital of Gannan Medical University, No. 23 Qingnian Road, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. li_longnian@foxmail.com
Research Domain of This Article
Dermatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhi-Wei Wu, Wen-Jie Zhu, Cong You, Long-Nian Li, Department of Dermatology, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
Shan Huang, Department of Laser and Cosmetic Dermatology, Ganzhou Dermatology Hospital, Ganzhou 341000, Jiangxi Province, China
Qi Tan, Department of Dermatology, Tongxiang Dermatology Hospital, Jiaxing 314000, Zhejiang Province, China
Dian-Gui Hu, Department of Infectious Diseases, The Fifth people’s Hospital of Ganzhou, Ganzhou 341000, Jiangxi Province, China
Author contributions: Li LN and You C conceptualized the design; Wu ZW, Zhu WJ, Huang S, and Tan Q conducted an investigation; You C, Wu ZW and Li LN perform software operations; Li LN, You C, and Hu DG to supervise; Li LN and Zhu WJ do the writing; Li LN conducts resource collection, writing and editing.
Informed consent statement: Informed written consent was obtained from the patient and her families for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Long-Nian Li, PhD, Associate Chief Physician, Department of Dermatology, First Affiliated Hospital of Gannan Medical University, No. 23 Qingnian Road, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. li_longnian@foxmail.com
Received: December 16, 2023 Peer-review started: December 16, 2023 First decision: January 10, 2024 Revised: January 19, 2024 Accepted: February 22, 2024 Article in press: February 22, 2024 Published online: March 16, 2024 Processing time: 86 Days and 17.2 Hours
Abstract
BACKGROUND
Eccrine porocarcinoma (EPC) is a rare skin tumor that mainly affects the elderly population. Tumors often present with slow growth and a good prognosis. EPCs are usually distinguished from other skin tumors using histopathology and immunohistochemistry. However, surgical management alone may be inadequate if the tumor has metastasized. However, currently, surgical resection is the most commonly used treatment modality.
CASE SUMMARY
A seventy-four-year-old woman presented with a slow-growing nodule in her left temporal area, with no obvious itching or pain, for more than four months. Histopathological examination showed small columnar and short spindle-shaped cells; thus, basal cell carcinoma was suspected. However, immunohistochemical analysis revealed the expression of cytokeratin 5/6, p63 protein, p16 protein, and Ki-67 antigen (40%), and EPC was taken into consideration. The skin biopsy was repeated, and hematoxylin and eosin staining revealed ductal differentiation in some cells. Finally, the patient was diagnosed with EPC, and Mohs micrographic surgery was performed. We adapted follow-up visits in a year and not found any recurrence of nodules.
CONCLUSION
This case report emphasizes the diagnosis and differentiation of EPC.
Core Tip: Eccrine porocarcinomas (EPCs) are rare skin tumors that grow slowly with no obvious discomfort. They are difficult to distinguish from basal cell carcinomas, particularly those that occur on the face. Histopathological examination and immunohistochemistry are necessary to diagnose atypical lesions, their importance is demonstrated in our case. Multiple biopsies at different times are necessary to visualize ductal differentiation in cells. Our case reported a brief period of EPC in the temporal region of an elderly woman. We hope that our case findings will help in better understanding of EPCs.
