Lou JX, Wu Y, Huhe M, Zhang JJ, Jia DW, Jiang ZY. Diagnosis of poorly differentiated adenocarcinoma of the stomach by confocal laser endomicroscopy: A case report. World J Clin Cases 2024; 12(8): 1481-1486 [PMID: 38576802 DOI: 10.12998/wjcc.v12.i8.1481]
Corresponding Author of This Article
Zhen-Yu Jiang, PhD, Doctor, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, No. 30 Hude Mulin Street, Qingshan District, Baotou 014000, Inner Mongolia Autonomous Region, China. jzhy1981@foxmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jia-Xin Lou, Yong Wu, Jing-Jie Zhang, Dong-Wu Jia, Zhen-Yu Jiang, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014030, Inner Mongolia Autonomous Region, China
Muren Huhe, Medical Innovation Center, The Fourth Military Medical University, Xi'an 710000, Shaanxi Province, China
Author contributions: Lou JX and Jiang ZY designed the research study; Wu Y, Huhe M, Zhang JJ and Jia DW performed the research and collected the case information; Lou JX analyzed the data and wrote the manuscript. All authors have read and approve the final manuscript.
Supported byThe Health Science and Technology Foundation of Inner Mongolia, No. 202201436; Science and Technology Innovation Foundation of Inner Mongolia, No. CXYD2022BT01.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Lou JX has received research funding from the Health Science and Technology Foundation of Inner Mongolia (202201436). Jiang ZY has received research funding from the Science and Technology Innovation Foundation of Inner Mongolia (CXYD2022BT01).
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Yu Jiang, PhD, Doctor, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, No. 30 Hude Mulin Street, Qingshan District, Baotou 014000, Inner Mongolia Autonomous Region, China. jzhy1981@foxmail.com
Received: December 9, 2023 Peer-review started: December 9, 2023 First decision: January 5, 2024 Revised: January 20, 2024 Accepted: February 25, 2024 Article in press: February 25, 2024 Published online: March 16, 2024 Processing time: 94 Days and 2.6 Hours
Abstract
BACKGROUND
In recent years, confocal laser endomicroscopy (CLE) has become a new endoscopic imaging technology at the microscopic level, which is extensively performed for real-time in vivo histological examination. CLE can be performed to distinguish benign from malignant lesions. In this study, we diagnosed using CLE an asymptomatic patient with poorly differentiated gastric adenocarcinoma.
CASE SUMMARY
A 63-year-old woman was diagnosed with gastric mucosal lesions, which may be gastric cancer, in the small curvature of the stomach by gastroscopy. She consented to undergo CLE for morphological observation of the gastric mucosa. Through the combination of CLE diagnosis and postoperative pathology, the intraoperative CLE diagnosis was considered to be reliable. According to our experience, CLE can be performed as the first choice for the diagnosis of gastric cancer.
CONCLUSION
CLE has several advantages over pathological diagnosis. We believe that CLE has great potential in the diagnosis of benign and malignant gastric lesions.
Core Tip: Confocal laser microscopic endoscope (CLE) is a relatively new endoscopic imaging technology. It provides a real-time microscopic vison of mucosal epithelium physiology and pathology in natural state. Gastric cancer is a common disease in clinic. Early symptoms are hidden, and patients do not pay enough attention to them. In this case, a woman was diagnosed gastric poorly differentiated adenocarcinoma by CLE in the small curvature by gastroscope. Through the combination of CLE and pathology, the intraoperative CLE diagnosis was considered to be reliable. According to our experience, CLE can be used as the first choice for the diagnosis of gastric cancer.
