Chen QN, Bai BQ, Xu Y, Mei Q, Liu XC. Sporadic gastrinoma with refractory benign esophageal stricture: A case report. World J Clin Cases 2024; 12(7): 1284-1289 [PMID: 38524517 DOI: 10.12998/wjcc.v12.i7.1284]
Corresponding Author of This Article
Xiao-Chang Liu, MD, Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, No. 219 Jixi Road, Shushan District, Hefei 230001, Anhui Province, China. liuchenxiaochang@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 6, 2024; 12(7): 1284-1289 Published online Mar 6, 2024. doi: 10.12998/wjcc.v12.i7.1284
Sporadic gastrinoma with refractory benign esophageal stricture: A case report
Qian-Nan Chen, Bing-Qing Bai, Yan Xu, Qiao Mei, Xiao-Chang Liu
Qian-Nan Chen, Bing-Qing Bai, Yan Xu, Qiao Mei, Xiao-Chang Liu, Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China
Author contributions: Chen QN designed and wrote the manuscript; Mei Q and Liu XC edited the manuscript; Bai BQ and Xu Y provided pathological data; All authors critically reviewed the manuscript and gave final approval for publication.
Informed consent statement: The requirement for informed consent was waived by the committee due to the retrospective study design.
Conflict-of-interest statement: All the authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Chang Liu, MD, Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, No. 219 Jixi Road, Shushan District, Hefei 230001, Anhui Province, China. liuchenxiaochang@163.com
Received: August 30, 2023 Peer-review started: August 30, 2023 First decision: December 2, 2023 Revised: December 25, 2023 Accepted: February 5, 2024 Article in press: February 5, 2024 Published online: March 6, 2024 Processing time: 184 Days and 0.7 Hours
Abstract
BACKGROUND
Gastrinoma is characterized by an excessive release of gastrin, leading to hypersecretion of gastric acid, subsequently resulting in recurrent peptic ulcers, chronic diarrhea, and even esophageal strictures. This case report aims to improve awareness and facilitate early diagnosis and treatment of gastrinoma by presenting a rare case of gastrinoma with refractory benign esophageal stricture (RBES). Additionally, it highlights the persistent challenges that gastroenterologists encounter in managing RBES.
CASE SUMMARY
This case demonstrates a patient with gastrinoma who developed RBES and complete esophageal obstruction despite management with maximal acid suppressive therapy, multiple endoscopic bougie dilations and endoscopic incisional therapy (EIT).
CONCLUSION
It is essential to diagnose gastrinoma as early as possible, as inadequately controlled acid secretion over an extended period increases the risk of developing severe esophageal strictures. In patients with esophageal strictures causing complete luminal obstruction, blind reopening EIT presents challenges and carries a high risk of perforation.
Core Tip: We report a rare case of sporadic gastrinoma in a young woman who presented with chronic diarrhea, multiple peptic ulcers, and a refractory benign esophageal stricture. The case indicates that inadequately controlled acid secretion over an extended period increases the risk of developing severe esophageal strictures. It also highlights that in patients with complete esophageal strictures, blind reopening endoscopic incisional therapy presents challenges and carries a high risk of perforation.
