Zhu JY, Liu MY, Sun C. Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation. World J Clin Cases 2024; 12(6): 1094-1103 [PMID: 38464922 DOI: 10.12998/wjcc.v12.i6.1094]
Corresponding Author of This Article
Chang Sun, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, No. 168 Changhai Road, Shanghai 200433, China. sunchang8211@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 26, 2024; 12(6): 1094-1103 Published online Feb 26, 2024. doi: 10.12998/wjcc.v12.i6.1094
Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation
Jing-Yi Zhu, Mu-Yun Liu, Chang Sun
Jing-Yi Zhu, Chang Sun, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
Mu-Yun Liu, Department of Gastroenterology, Navy No. 905 Hospital, Naval Medical University, Shanghai 200433, China
Author contributions: All contributors participated in study formulation and design. Zhu JY prepared the initial draft of the manuscript; Liu MY prepared, collected, and analyzed the data; Sun C revised and reviewed the manuscript; the manuscript was accepted for publication after final approval from the authors.
Institutional review board statement: The NHANES is a publicly available database, and this research was reviewed and approved by the Research Ethics Review Board of the National Center for Health Statistics.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: The dataset supporting the conclusions of this article is available in the NHANES repository: NHANES-National Health and Nutrition Examination Survey Homepage (cdc.gov).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang Sun, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, No. 168 Changhai Road, Shanghai 200433, China. sunchang8211@163.com
Received: December 8, 2023 Peer-review started: December 8, 2023 First decision: December 20, 2023 Revised: January 3, 2024 Accepted: January 19, 2024 Article in press: January 19, 2024 Published online: February 26, 2024
Abstract
BACKGROUND
Accumulating evidence suggests that the gut microbiome is involved in the pathogenesis of insulin resistance (IR). However, the link between two of the most prevalent bowel disorders, chronic diarrhea and constipation, and the triglyceride glucose (TyG) index, a marker of IR, has not yet been investigated.
AIM
To investigate the potential association between TyG and the incidence of chronic diarrhea and constipation.
METHODS
This cross-sectional study enrolled 2400 participants from the National Health and Nutrition Examination Survey database from 2009-2010. TyG was used as an exposure variable, with chronic diarrhea and constipation as determined by the Bristol Stool Form Scale used as the outcome variables. A demographic investigation based on TyG quartile subgroups was performed. The application of multivariate logistic regression models and weighted generalized additive models revealed potential correlations between TyG, chronic diarrhea, and constipation. Subgroup analyses were performed to examine the stability of any potential associations.
RESULTS
In the chosen sample, chronic diarrhea had a prevalence of 8.00%, while chronic constipation had a prevalence of 8.04%. In multiple logistic regression, a more prominent positive association was found between TyG and chronic diarrhea, particularly in model 1 (OR = 1.45; 95%CI: 1.17-1.79, P = 0.0007) and model 2 (OR = 1.40; 95%CI: 1.12-1.76, P = 0.0033). No definite association was observed between the TyG levels and chronic constipation. The weighted generalized additive model findings suggested a more substantial positive association with chronic diarrhea when TyG was less than 9.63 (OR = 1.89; 95%CI: 1.05-3.41, P = 0.0344), and another positive association with chronic constipation when it was greater than 8.2 (OR = 1.74; 95%CI: 1.02-2.95, P = 0.0415). The results of the subgroup analyses further strengthen the extrapolation of these results to a wide range of populations.
CONCLUSION
Higher TyG levels were positively associated with abnormal bowel health.
Core Tip: Chronic diarrhea and constipation are two common conditions that interfere with daily life. Herein, we identified a positive association between the triglyceride glucose index, a marker of insulin resistance (IR), and chronic diarrhea in the National Health and Nutrition Examination Survey database. These results suggest that early and comprehensive management of IR may be beneficial for maintaining normal bowel health. Further investigations should be conducted on the underlying pathological mechanisms.
