Dimova A, Boroš M, Dimov S, Konjevod J, Svetec M. Platelet-rich plasma treatment for chronic wounds: A case report and literature review. World J Clin Cases 2024; 12(33): 6635-6643 [PMID: 39600480 DOI: 10.12998/wjcc.v12.i33.6635]
Corresponding Author of This Article
Ana Dimova, MD, Surgeon, Department of Surgery, Zabok General Hospital and the Croatian Veterans Hospital, Bračak 8, Zabok 49210, Croatia. ana.dimova@svkatarina.hr
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2024; 12(33): 6635-6643 Published online Nov 26, 2024. doi: 10.12998/wjcc.v12.i33.6635
Platelet-rich plasma treatment for chronic wounds: A case report and literature review
Ana Dimova, Martin Boroš, Stefan Dimov, Janja Konjevod, Maja Svetec
Ana Dimova, Martin Boroš, Stefan Dimov, Janja Konjevod, Department of Surgery, Zabok General Hospital and the Croatian Veterans Hospital, Zabok 49210, Croatia
Ana Dimova, Stefan Dimov, Department of Surgery, St Catherine Specialty Hospital, Zagreb 10000, Croatia
Maja Svetec, Department of Emergency Medicine, Zabok General Hospital and the Croatian Veterans Hospital, Zabok 49210, Croatia
Author contributions: Dimova A and Boroš M conceived of and designed the study; Dimova A, Dimov S, and Svetec M acquired the data; Dimova A, Boroš M, and Konjevod J drafted the manuscript; All authors analyzed and interpreted the data, critically reviewed the manuscript for important intellectual content, gave approval of the version to be submitted, and agree to be accountable for all aspects of the work.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Conflict-of-interest statement: The authors declare no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ana Dimova, MD, Surgeon, Department of Surgery, Zabok General Hospital and the Croatian Veterans Hospital, Bračak 8, Zabok 49210, Croatia. ana.dimova@svkatarina.hr
Received: June 30, 2024 Revised: August 17, 2024 Accepted: September 2, 2024 Published online: November 26, 2024 Processing time: 88 Days and 11.6 Hours
Abstract
BACKGROUND
Wound healing is a complicated process that can be heavily influenced by patient comorbidities, in some cases leading to a chronic non-healing wound. Evidence presented in the medical literature supporting the clinical use of autologous platelet-rich plasma (PRP) in treatment of such wounds is becoming increasingly compelling. Mechanisms involved include complex interactions between the patient’s thrombocytes, cytokines, and growth factors.
CASE SUMMARY
We present a case of a 72-year-old male patient with a long-standing chronic wound and multiple comorbidities. Over the course of more than 7 months, the patient was unsuccessfully treated with all routinely used measures, including different dressing approaches. Multiple antibiotic regimens were administered for wound infection, with repeated evaluation of microbiological swab results. Finally, after three PRP applications, the wound showed clinical improvement with complete restitution of the epithelial layer of the skin.
CONCLUSION
PRP treatment may be beneficial to reduce healing time in chronic wounds.
Core Tip: Chronic wounds present a huge burden on healthcare systems worldwide, and diminish the quality of life of affected patients tremendously. Chronic wounds are often a source of frustration for attending clinicians as well, since many different types of dressings and other forms of conservative therapy and surgical debridement are used. We believe that local platelet-rich plasma (PRP) application is an easily performed procedure that could be offered to patients with chronic wounds after the failure of standard dressing-type procedures. We also believe that other more invasive regenerative treatment options should be postponed until after PRP is attempted.
