Martínez Nieto M, González Gómez LA, Gómez Mireles JC, Lomelí Martínez SM. Diagnostic and therapeutic challenges of myeloid sarcoma in the oral cavity. World J Clin Cases 2024; 12(32): 6526-6533 [PMID: 39554898 DOI: 10.12998/wjcc.v12.i32.6526]
Corresponding Author of This Article
Sarah Monserrat Lomelí Martínez, PhD, Academic Research, Adjunct Associate Professor, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, Col. Lindavista, Ocotlán 47810, Mexico. sarah.lomeli@academicos.udg.mx
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 16, 2024; 12(32): 6526-6533 Published online Nov 16, 2024. doi: 10.12998/wjcc.v12.i32.6526
Diagnostic and therapeutic challenges of myeloid sarcoma in the oral cavity
Melissa Martínez Nieto, Luis Antonio González Gómez, Juan Carlos Gómez Mireles, Sarah Monserrat Lomelí Martínez
Melissa Martínez Nieto, Luis Antonio González Gómez, Juan Carlos Gómez Mireles, Department of Integrated Dentistry Clinics, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico
Sarah Monserrat Lomelí Martínez, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán 47810, Mexico
Sarah Monserrat Lomelí Martínez, Department of Well-being and Sustainable Development, Centro Universitario del Norte, Universidad de Guadalajara, Colotlan 46200, Jalisco, Mexico
Author contributions: All authors contributed equally to the preparation of this manuscript; Lomelí Martínez SM and Martínez Nieto M conceived the idea; Lomelí Martínez SM, Martínez Nieto M, and González Gómez LA did the literature search; Lomelí Martínez SM, Gómez Mireles JC, Martínez Nieto M, and González Gómez LA wrote the preliminary draft; Lomelí Martínez SM, Gómez Mireles JC, Martínez Nieto M, and González Gómez LA critically reviewed and approved the manuscript.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sarah Monserrat Lomelí Martínez, PhD, Academic Research, Adjunct Associate Professor, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, Col. Lindavista, Ocotlán 47810, Mexico. sarah.lomeli@academicos.udg.mx
Received: June 1, 2024 Revised: August 8, 2024 Accepted: August 12, 2024 Published online: November 16, 2024 Processing time: 114 Days and 15.1 Hours
Abstract
Myeloid sarcoma (MS) is a rare neoplasm characterized by the proliferation of immature myeloid precursor cells outside the bone marrow. The pathogenesis of MS is complex and not completely understood. Moreover, it develops in any extramedullary site of the body. In this editorial, we discuss the article published by Li et al, which presents a clinical case involving a 32-year-old man who exhibited gingival inflammation in the maxillary region. It was initially diagnosed as periodontal disease. However, clinical evaluation revealed a firm, grayish-white mass which underscored the need for comprehensive diagnostics to distinguish MS from other oral conditions. This article emphasizes the different clinical presentations of similar case studies in the literature, and highlights the difficulty in diagnosing oral MS due to its rarity and variability in clinical manifestation. The treatment of MS depends on the clinical presentation, tumor location, and the patient's response to conventional therapies. The various therapeutic options currently available are analyzed and discussed. Early intervention and multidisciplinary management are crucial for improving treatment outcomes. Increased awareness and education about the various clinical presentations of MS lead to earlier diagnosis and timely treatment, thereby enhancing patients' survival and quality of life. Continued research is essential for optimizing therapeutic strategies and addressing the challenges presented by this rare neoplasm.
Core Tip: In this editorial, we highlight the analysis of oral myeloid sarcoma (MS) as discussed in the article by Li et al. We examine the diagnostic and therapeutic challenges inherent in MS, with focus on its diverse clinical presentations, particularly in the gingival tissue, and review the relevant literature. We emphasize the importance of understanding the pathogenesis of MS, the role of dental professionals in early detection of the disease, and the various treatment options available, such as chemotherapy, radiotherapy, stem cell transplantation, targeted therapies, and immunomodulatory therapies.
