Hao WR, Cheng CY, Liu JC, Cheng TH. Unraveling autophagy-related pathogenesis in active ulcerative colitis: A bioinformatics approach. World J Clin Cases 2024; 12(30): 6335-6338 [PMID: 39464329 DOI: 10.12998/wjcc.v12.i30.6335]
Corresponding Author of This Article
Tzu-Hurng Cheng, PhD, Professor, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, No. 91 Xueshi Road, North District, Taichung City 404333, Taiwan. thcheng@mail.cmu.edu.tw
Research Domain of This Article
Medical Informatics
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Wen-Rui Hao, Ju-Chi Liu, Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei City 23561, Taiwan
Wen-Rui Hao, Ju-Chi Liu, Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11002, Taiwan
Chun-Yao Cheng, Department of Medical Education, National Taiwan University Hospital, Taipei 100225, Taiwan
Chun-Yao Cheng, Department of Ophthalmology, Cathay General Hospital, Taipei 10633, Taiwan
Tzu-Hurng Cheng, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung City 404333, Taiwan
Co-corresponding authors: Ju-Chi Liu and Tzu-Hurng Cheng.
Author contributions: Hao WR and Cheng CY wrote the initial paper; Liu JC and Cheng TH revised the paper. All authors have read and approved the final manuscript. Hao WR and Cheng CY provided the initial draft of the editorial, synthesizing the key findings and implications of Gong et al’s study. Liu JC and Cheng TH played crucial roles in revising the manuscript, ensuring it accurately reflects the significance of the findings and their implications for future research and clinical practice. Liu JC contributed his expertise in interpreting the relevance of the bioinformatics approach and the identified autophagy-related genes. Cheng TH provided valuable insights into the broader context of the study, guiding the narrative to emphasize the clinical importance of the findings. Both Liu and Cheng were essential in refining the editorial's structure, integrating feedback from co-authors, and finalizing the manuscript for submission. Their substantial and indispensable contributions to the manuscript's development and their guidance throughout the revision process justify their roles as co-corresponding authors.
Conflict-of-interest statement: All authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tzu-Hurng Cheng, PhD, Professor, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, No. 91 Xueshi Road, North District, Taichung City 404333, Taiwan. thcheng@mail.cmu.edu.tw
Received: March 10, 2024 Revised: July 2, 2024 Accepted: July 17, 2024 Published online: October 26, 2024 Processing time: 178 Days and 5 Hours
Abstract
In this editorial, we provide commentary on the study by Gong et al. In this original research article, Gong et al employed a bioinformatics approach to investigate the involvement of autophagy in active ulcerative colitis (UC). Through differential gene expression analysis, they identified 58 differentially expressed autophagy-related genes in UC patients compared to healthy controls. Notably, HSPA5, CASP1, SERPINA1, CX3CL1, and BAG3, were found to be upregulated in active UC patients, suggesting their significance as core autophagy-related targets. Enrichment analysis unveiled associations with crucial signaling pathways and diseases such as middle cerebral artery occlusion and glomerulonephritis. Moreover, immune cell infiltration analysis revealed notable differences in immune cell composition between UC patients and healthy controls. These findings offer valuable insights into the role of autophagy in UC pathogenesis and potential therapeutic targets.
Core Tip: The study by Gong et al highlights HSPA5, CASP1, SERPINA1, CX3CL1, and BAG3 as core autophagy-related targets upregulated in active ulcerative colitis (UC) patients. Enrichment analysis underscores the involvement of autophagy in key signaling pathways and diseases associated with UC. Immune cell infiltration analysis emphasizes the importance of immune dysregulation in UC progression. These findings provide crucial insights into the molecular mechanisms underlying UC pathogenesis and may guide the development of personalized treatment strategies for UC patients.
