Chang J, Li X. Multivariate analysis of oral mucosal ulcers during orthodontic treatment. World J Clin Cases 2024; 12(26): 5868-5876 [PMID: 39286371 DOI: 10.12998/wjcc.v12.i26.5868]
Corresponding Author of This Article
Xue Li, PhD, Doctor, The Fifth Clinic, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No. 22 Zhongguancun South Street, Beijing 100081, China. lixue4337@126.com
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 16, 2024; 12(26): 5868-5876 Published online Sep 16, 2024. doi: 10.12998/wjcc.v12.i26.5868
Multivariate analysis of oral mucosal ulcers during orthodontic treatment
Jing Chang, Xue Li
Jing Chang, Xue Li, The Fifth Clinic, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing 100081, China
Author contributions: Chang J and Li X wrote, revised, and reviewed the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of the School and Hospital of Stomatology of Peking University on January 2, 2020.
Informed consent statement: All enrolled patients were informed of the research purpose, and signed informed consent was obtained from each patient.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: All data and materials are available from the corresponding author upon reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue Li, PhD, Doctor, The Fifth Clinic, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No. 22 Zhongguancun South Street, Beijing 100081, China. lixue4337@126.com
Received: March 11, 2024 Revised: May 6, 2024 Accepted: May 24, 2024 Published online: September 16, 2024 Processing time: 134 Days and 3.5 Hours
Abstract
BACKGROUND
Orthodontic treatment can easily cause local soft tissue reactions in the oral cavity of patients under mechanical stress, leading to oral mucosal ulcers and affecting their quality of life. At present, only limited literature has explored the factors leading to oral ulcers in orthodontic treatment, and these research results are still controversial.
AIM
To investigate the current status and related factors of oral mucosal ulcers during orthodontic treatment, aiming to provide a valuable reference for preventing this disease in clinical practice.
METHODS
A total of 587 patients who underwent orthodontic treatment at the Peking University School of Stomatology and Hospital of Stomatology between 2020 and 2022 were selected and allocated to an observation or control group according to the incidence of oral mucosal ulcers during orthodontic therapy. A questionnaire survey was constructed to collect patient data, including basic information, lifestyle and eating habits, treatment details, mental factors, and trace element levels, and a comparative analysis of this data was performed between the two groups.
RESULTS
A logistic regression model with oral ulcers as the dependent variable was established. The regression results showed that age (≥ 60 years: odds ratio [OR]: 6.820; 95% confidence interval [CI]: 2.226–20.893), smoking history (smoking: OR: 4.434; 95%CI: 2.527–7.782), toothbrush hardness (hard: OR: 2.804; 95%CI: 1.746–4.505), dietary temperature (hot diet: OR: 1.399; 95%CI: 1.220–1.722), treatment course (> 1 year: OR: 3.830; 95%CI: 2.203–6.659), and tooth brushing frequency (> 1 time per day: OR: 0.228; 95%CI: 0.138–0.377) were independent factors for oral mucosal ulcers (P < 0.05). Furthermore, Zn level (OR: 0.945; 95%CI: 0.927–0.964) was a protective factor against oral ulcers, while the SAS (OR: 1.284; 95%CI: 1.197–1.378) and SDS (OR: 1.322; 95%CI: 1.231–1.419) scores were risk factors.
CONCLUSION
Age ≥ 60 years, smoking history, hard toothbrush, hot diet, treatment course for > 1 year, tooth brushing frequency of ≤ 1 time per day, and mental anxiety are independent risk factors for oral mucosal ulcers. Therefore, these factors should receive clinical attention and be incorporated into the development and optimization of preventive strategies for reducing oral ulcer incidence.
Core Tip: Currently, there is limited literature exploring the factors leading to oral ulcers during orthodontic treatment, with considerable controversy. Therefore, this study uses retrospective data to explore and analyze the current situation and related factors of oral mucosal ulcers during orthodontic treatment in our hospital, providing a reference for the clinical prevention of this disease.
