Randomized Controlled Trial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2024; 12(24): 5558-5567
Published online Aug 26, 2024. doi: 10.12998/wjcc.v12.i24.5558
Application of buried auricular point combined with Wenjing Sanhan prescription in arteriosclerosis obliterans patients with resting pain
Ya-Ping Li, Tian Su, Xiao-Li Xue, Huan-Ren Shi, Zhi-Hui Su, Jun Li
Ya-Ping Li, Tian Su, Xiao-Li Xue, Huan-Ren Shi, Zhi-Hui Su, Jun Li, Department of Vascular, Shijiazhuang Hospital of Traditional Chinese Medicine (Eastern Hospital District), Shijiazhuang 050011, Hebei Province, China
Author contributions: Li J designed the research; Li YP performed the research and wrote the paper; Su T, Su ZH, and Xue XL contributed new reagents or analytic tools; Shi HR analyzed the data.
Supported by the Scientific Research Program of Hebei Provincial Administration of Traditional Chinese Medicine, No. 2020342.
Institutional review board statement: The study was reviewed and approved by the Shijiazhuang Hospital of Traditional Chinese Medicine Institutional Review Board, No. HB20191095.
Clinical trial registration statement: This study was not registered.
Informed consent statement: All subjects understood and agreed to the study protocol, and voluntarily signed the informed consent form.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Li, Doctor, MA, Chief Doctor, Executive Director, Department of Vascular, Shijiazhuang Hospital of Traditional Chinese Medicine (Eastern Hospital District), No. 138 North Jianhua Street, Shijiazhuang 050011, Hebei Province, China. dymgk68068078@163.com
Received: April 30, 2024
Revised: May 29, 2024
Accepted: June 18, 2024
Published online: August 26, 2024
Processing time: 71 Days and 22.7 Hours
Abstract
BACKGROUND

Research on the combined use of ear acupoint embedding beans and warming meridians with cold-dispersing formulas for alleviating resting pain in patients with arteriosclerosis obliterans (ASO) remains limited.

AIM

To explore the therapeutic efficacy of auricular point embedding beans combined with Wenjing Sanhan prescription in alleviating resting pain in patients with lower-limb ASO.

METHODS

A total of 100 patients with ASO experiencing resting pain who were treated at our hospital from January 2022 to January 2023 were enrolled. They were randomly allocated into two groups using a double-blind approach. The control group was treated using a warming meridian with a cold-dispersing formula, while the study group received additional treatment with ear acupoint embedding beans. The clinical efficacy, ankle-brachial artery pressure ratio, hemorheological indicators, and traditional Chinese medicine symptom scores were compared between the two groups.

RESULTS

The clinical efficacy rate in the study group was significantly higher (94.00%) than that in the control group (72.00%, P < 0.05). Moreover, the ankle-brachial artery pressure ratio was significantly higher in the study group after treatment (P < 0.05). Hemorheological parameters, including whole blood viscosity, plasma viscosity (1.83 ± 0.11) mPa/s, fibrinogen levels (3.30 ± 0.21) g/L, platelet adhesion rate (49.87% ± 10.51%), and erythrocyte aggregation index (1.79 ± 0) were improved in the study group compared to the control group. In addition, the scores for decreased skin temperature (1.41 ± 0.26), intermittent claudication (1.30 ± 0.20), and resting pain (1.23 ± 0.31) were significantly lower in the study group than those in the control group (all P < 0.05). The level of oxidative stress in the study group also exhibited significant improvement (P < 0.05), and the levels of inflammatory factors were considerably lower than those in the control group.

CONCLUSION

The combination of ear point embedding beans and Wenjing Sanhan prescription demonstrates promising clinical efficacy in alleviating resting pain associated with ASO.

Keywords: Embedding beans in ear acupoints, Prescription for warming channels and dispelling cold, Lower limb arteriosclerosis obliterans, Resting pain, Blood flow rheology, Curative effect

Core Tip: The combination of ear point embedding beans and Wenjing Sanhan prescription demonstrates promising clinical efficacy in alleviating resting pain associated with arteriosclerosis obliterans. It substantially improves the ankle-brachial artery pressure ratio, reduces hemorheological abnormalities and traditional Chinese medicine symptom scores, and alleviates resting pain.