Dong GF, Hou YK, Ma Q, Ma SY, Wang YJ, Rexiati M, Wang WG. Cushing's syndrome caused by giant Ewing's sarcoma of the kidney: A case report and review of literature. World J Clin Cases 2024; 12(23): 5431-5440 [DOI: 10.12998/wjcc.v12.i23.5431]
Corresponding Author of This Article
Wen-Guang Wang, MD, Associate Professor, Chief Doctor, Surgeon, Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyu Shan South Road, High-tech Zone, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. wwg0903@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Guo-Fan Dong, Ya-Kun Hou, Qi Ma, Shuang-Yu Ma, Yu-Jie Wang, Mulati Rexiati, Wen-Guang Wang, Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Co-first authors: Guo-Fan Dong and Ya-Kun Hou.
Author contributions: Dong GF and Hou YK wrote the main manuscript text, contributed equally to this paper; Ma Q and Ma SY prepared the figures. Wang YJ and Rexiati M were responsible for conceptualization and supervision; Wang WG was responsible for supervision and replied to peer review. All the authors reviewed their participation in the treatment and reviewed the manuscript.
Informed consent statement: The use of human blood samples was in accordance with the legislation in China. Informed consent was obtained from the relatives of the patient. Written informed consent was obtained from the patient's relatives for the publication of this case report and any accompanying images.
Conflict-of-interest statement: We declare that there are no conflicts of interest between the authors.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Guang Wang, MD, Associate Professor, Chief Doctor, Surgeon, Department of Urologic Surgery, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyu Shan South Road, High-tech Zone, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. wwg0903@163.com
Received: April 14, 2024 Revised: June 6, 2024 Accepted: June 26, 2024 Published online: August 16, 2024 Processing time: 81 Days and 20.4 Hours
Abstract
BACKGROUND
Primary renal Ewing’s sarcoma (ES) is extremely rare, and only two cases causing Cushing’s syndrome (CS) have been reported to date. We report that the case of an 18-year-old patient is diagnosed primary renal ES with typical CS characterized by purple stripes, weight gain, and hypertension.
CASE SUMMARY
CS was first diagnosed by laboratory testing. A huge tumor was revealed in the kidney following an imaging examination. Moreover, brain and bone metastases were observed. After comprehensive treatment, primarily based on surgery, primary renal ES was pathologically diagnosed with a typical EWSR1-FLI1 genetic mutation through genetic testing. Furthermore, the glucocorticoid level returned to normal. By the ninth postoperative month of follow-up, the patient was recovering well. Cushing-related symptoms had improved, and a satisfactory curative effect was achieved.
CONCLUSION
Primary renal ES, a rare adult malignant tumor, can cause CS and a poor prognosis.
Core Tip: Primary renal Ewing's sarcoma (ES), a rare adult malignant tumor, can cause Cushing syndrome and a poor prognosis. The "gold standard" for diagnosing primary renal ES remains pathological examination, even though gene studies can aid in diagnosis and therapy planning. When treating advanced metastatic primary renal ES, a comprehensive surgical approach centered on surgery can produce specific outcomes.
