Yang SY, Wang JZ, Fan H, Chen M. Adrenaline in pulp capping treatment of reversible pulpitis. World J Clin Cases 2024; 12(22): 5024-5031 [DOI: 10.12998/wjcc.v12.i22.5024]
Corresponding Author of This Article
Min Chen, MD, Doctor, Department of Stomatology, Anhui Jieshou People's Hospital, No. 399 Renmin East Road, Fuyang 236500, Anhui Province, China. fly1573@126.com
Research Domain of This Article
Pharmacology & Pharmacy
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2024; 12(22): 5024-5031 Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5024
Adrenaline in pulp capping treatment of reversible pulpitis
Si-Yun Yang, Jin-Zhu Wang, Hao Fan, Min Chen
Si-Yun Yang, Hao Fan, Min Chen, Department of Stomatology, Anhui Jieshou People's Hospital, Fuyang 236500, Anhui Province, China
Jin-Zhu Wang, Department of Stomatology, Jiangsu Yancheng Maternal and Child Health Hospital, Yancheng 224000, Jiangsu Province, China
Author contributions: Yang SY drafted the manuscript, and assisted with data analysis; Chen M participated in the design and oversight of the study, and was involved with data collection; Wang JZ participated in the design of the study, and was involved with data collection; Fan H was involved with data collection, and assisted with data analyses; All authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by Anhui Jieshou People's Hospital Institutional Review Board, No. 2019-11-001.
Informed consent statement: All subjects understood and agreed to the study protocol and voluntarily signed the informed consent form.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min Chen, MD, Doctor, Department of Stomatology, Anhui Jieshou People's Hospital, No. 399 Renmin East Road, Fuyang 236500, Anhui Province, China. fly1573@126.com
Received: February 29, 2024 Revised: April 23, 2024 Accepted: June 11, 2024 Published online: August 6, 2024 Processing time: 123 Days and 24 Hours
Abstract
BACKGROUND
The role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis is not clear.
AIM
To explore the role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis.
METHODS
A total of 100 patients with reversible pulpitis who were treated in Anhui Jieshou People's Hospital from January 2020 to December 2021 were included in the study. They were categorized into an observation group (n = 50; treatment with adrenaline) and a control group (n = 50; treatment with zinc oxide eugenol paste). The 24-h postoperative pain, regression time of gingival congestion and redness, clinical efficacy, and incidence of adverse reactions were compared between the groups. Patients were further categorized into the ineffective and effective treatment groups based on clinical efficacy. Logistic multiple regression analysis explored factors affecting the efficacy of pulp capping treatment.
RESULTS
A significant difference in 24-h postoperative pain was observed between the groups (P < 0.05), with a higher proportion of grade I pain noted in the observation group than in the control group (P < 0.01). The regression time of gingival congestion and swelling was lower in the observation group (2.61 ± 1.44 d and 2.73 ± 1.36 d, respectively) than in the control group (3.85 ± 1.47 d and 4.28 ± 1.61 d, respectively) (P < 0.05). The 2-wk postoperative total effective rate was lower in the control group (80.00%) than in the observation group (94.00%) (P < 0.05). The incidence of adverse reactions was not significantly different between the control (14.00%) and observation (12.00%) groups (P > 0.05). The proportion of adrenaline usage was lower (P < 0.05) and that of anaerobic digestion by Streptococcus and Fusobacterium nucleatum was higher in the ineffective treatment group than in the effective treatment group (P < 0.05). Logistic multiple regression analysis revealed adrenaline as a protective factor (P < 0.05) and anaerobic digestion by Streptococcus and F. nucleatum as risk factors for pulp capping in reversible pulpitis (P < 0.05).
CONCLUSION
Adrenaline demonstrated therapeutic efficacy in pulp capping treatment for reversible pulpitis, reducing pain and improving clinical symptoms safely. It is a protective factor for pulp capping, whereas Streptococcus and F. nucleatum are risk factors. Targeted measures can be implemented to improve clinical efficacy.
Core Tip: Reversible pulpitis is an inflammatory disease characterized by vasodilation and congestion of pulp tissue as the main pathological changes following infection and stimulation by cold and heat. It is speculated that adrenaline might improve the symptoms of congestion and swelling in the tissues surrounding the pulp in patients with reversible pulpitis. This study included 100 patients with reversible pulpitis to explore the role of adrenaline in pulp capping treatment in patients with reversible pulpitis and its analgesic and hemostatic effects and safety. Adrenaline demonstrated therapeutic efficacy in pulp capping treatment for reversible pulpitis, reducing pain and improving clinical symptoms safely.
