Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5008
Revised: June 9, 2024
Accepted: June 18, 2024
Published online: August 6, 2024
Processing time: 55 Days and 20.4 Hours
Coronary heart disease and type 2 diabetes mellitus (T2DM) frequently coexist, creating a complex and challenging clinical scenario, particularly when comp
To examine the effects of dapagliflozin combined with sakubactrovalsartan sodium tablets on myocardial microperfusion.
In total, 98 patients were categorized into control (n = 47) and observation (n = 51) groups. The control group received noxital, while the observation group was treated with dapagliflozin combined with noxital for 6 months. Changes in myocardial microperfusion, blood glucose level, cardiac function, N-terminal prohormone of brain natriuretic peptide (NT-proBNP) level, growth differentiation factor-15 (GDF-15) level, and other related factors were compared between the two groups. Additionally, the incidence of major adverse cardiovascular events (MACE) and adverse reactions were calculated.
After treatment, in the observation and control groups, the corrected thrombolysis in myocardial infarction frame counts were 37.12 ± 5.02 and 48.23 ± 4.66, respectively. The NT-proBNP levels were 1502.65 ± 255.87 and 2015.23 ± 286.31 pg/mL, the N-terminal pro-atrial natriuretic peptide (NT-proANP) levels were 1415.69 ± 213.05 and 1875.52 ± 241.02 ng/mL, the GDF-15 levels were 0.87 ± 0.43 and 1.21 ± 0.56 g/L, and the high-sensitivity C-reactive protein (hs-CRP) levels were 6.54 ± 1.56 and 8.77 ± 1.94 mg/L, respectively, with statistically significant differences (P < 0.05). The cumulative incidence of MACEs in the observation group was significantly lower than that in the control group (P < 0.05). The incidence of adverse reactions was 13.73% (7/51) in the observation group and 10.64% (5/47) in the control group, with no statistically significant difference (P > 0.05).
Dapagliflozin combined with nocinto can improve myocardial microperfusion and left ventricular remodeling and reduce MACE incidence in patients with post-AMI heart failure and T2DM. The underlying mechanism may be related to the reduction in the expression levels of NT-proANP, GDF-15, and hs-CRP.
Core Tip: This study explored the efficacy of combining dapagliflozin and sakubactrovalsartan (noxinto) in improving myocardial microperfusion and reducing major adverse cardiovascular event incidence in patients with post–acute myocardial infarction (AMI) heart failure and type 2 diabetes mellitus (T2DM). Results indicated that compared with the control group, significant improvements in myocardial perfusion, blood glucose levels, and cardiac function along with reductions in N-terminal pro-atrial natriuretic peptide, growth differentiation factor-15, and high-sensitivity C-reactive protein levels were noted in the observation group. These findings revealed that this combination therapy may offer a novel approach for managing complex cases of post-AMI heart failure and T2DM, highlighting its potential benefits and mechanisms of action.