Xie HT, An DH, Wu DB. Intracranial hypertension as the primary symptom of malignant melanoma: A case report. World J Clin Cases 2024; 12(21): 4836-4841 [PMID: 39070805 DOI: 10.12998/wjcc.v12.i21.4836]
Corresponding Author of This Article
Duo-Bin Wu, MD, PhD, Professor, Department of Neurology, Zhujiang Hospital of Southern Medical University, No. 253 Industry Road, Haizhu District, Guangzhou 510282, Guangdong Province, China. 936861404@qq.com
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2024; 12(21): 4836-4841 Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4836
Intracranial hypertension as the primary symptom of malignant melanoma: A case report
Hai-Ting Xie, Ding-Hao An, Duo-Bin Wu
Hai-Ting Xie, Department of Neurology, Southern Medical University, Guangzhou 510282, Guangdong Province, China
Ding-Hao An, Department of Neurology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210008, Jiangsu Province, China
Duo-Bin Wu, Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China
Co-first authors: Hai-Ting Xie and Ding-Hao An.
Author contributions: Xie HT, An DH, and Wu DB designed the study; Xie HT and An DH performed the research; An DH obtained the consent form of the patient; Xie HT and An DH wrote the manuscript; Wu DB reviewed and revised the manuscript; All authors have read and approved the final manuscript.
Informed consent statement: An informed consent form was signed by the parents of the case patient to approve the use of patient information or material for scientific purposes.
Conflict-of-interest statement: All authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Duo-Bin Wu, MD, PhD, Professor, Department of Neurology, Zhujiang Hospital of Southern Medical University, No. 253 Industry Road, Haizhu District, Guangzhou 510282, Guangdong Province, China. 936861404@qq.com
Received: April 19, 2024 Revised: May 19, 2024 Accepted: June 7, 2024 Published online: July 26, 2024 Processing time: 72 Days and 23.4 Hours
Abstract
BACKGROUND
The etiological diagnosis of intracranial hypertension is quite complicated but important in clinical practice. Some common causes are craniocerebral injury, intracranial space-occupying lesion, subarachnoid hemorrhage, and hydrocephalus. When a patient presents with intracranial hypertension, the common causes are to be considered first so that other causes would be dismissed. With the morbidity lower than 9%, neuromelanin is very rare. Common symptoms include nerve damage symptoms, epilepsy, psychiatric symptoms, and cognitive disorders.
CASE SUMMARY
We present a patient with melanoma which manifested with isolated intracranial hypertension without any other neurological signs. A 22-year-old male had repeated nausea and vomiting for 2 mo with Babinski sign (+) on both sides, nuchal rigidity, and subarachnoid hemorrhage. He had been diagnosed with melanoma and was given surgery and whole-brain radiation. Ultimately, the patient died 2 mo later.
CONCLUSION
Malignant melanoma should be taken into consideration in the differential diagnosis of intracranial hypertension.
Core Tip: This manuscript is a case report. We report on a patient with malignant melanoma who primarily presented with intracranial hypertension. With no other symptoms except intracranial hypertension, the process of etiological diagnosis was hard and thought-provoking. Moreover, there are few melanoma cases that manifested with intracranial hypertension alone.
