He ML, Zheng Y, Tian SX. Cronkhite-Canada syndrome complicated with pulmonary embolism: A case report. World J Clin Cases 2024; 12(21): 4820-4826 [PMID: 39070830 DOI: 10.12998/wjcc.v12.i21.4820]
Corresponding Author of This Article
Shu-Xin Tian, MD, PhD, Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Shihezi University, No. 107 North Second Road, Hongshan Street, Shihezi 832008, Xinjiang Uygur Autonomous Region, China. endo0726@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2024; 12(21): 4820-4826 Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4820
Cronkhite-Canada syndrome complicated with pulmonary embolism: A case report
Mao-Lang He, Yong Zheng, Shu-Xin Tian
Mao-Lang He, College of Medicine, Shihezi University, Shihezi 832099, Xinjiang Uygur Autonomous Region, China
Yong Zheng, Shu-Xin Tian, Department of Gastroenterology, The First Affiliated Hospital of Shihezi University, Shihezi 832008, Xinjiang Uygur Autonomous Region, China
Author contributions: He ML, Tian SX contributed to the study concept and design; He ML acquired the data and drafted the manuscript; He ML, Tian SX and Zheng Y critically revised the manuscript for important intellectual content; All authors approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have viewed the CARE Checklist (2016) and revised the manuscript according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Xin Tian, MD, PhD, Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Shihezi University, No. 107 North Second Road, Hongshan Street, Shihezi 832008, Xinjiang Uygur Autonomous Region, China. endo0726@163.com
Received: April 17, 2024 Revised: May 23, 2024 Accepted: June 11, 2024 Published online: July 26, 2024 Processing time: 74 Days and 20.4 Hours
Abstract
BACKGROUND
Cronkhite-Canada syndrome (CCS) is a rare disease, that causes gastrointestinal polyps, ectodermal abnormalities, and gastrointestinal symptoms. CCS is prone to thromboembolism, but clinical workers have not yet established a clinical consciousness of preventing thromboembolism. The present case illustrates pulmonary embolism (PE) complicated by CCS.
CASE SUMMARY
A 46-year-old male patient presented with mucus, purulent, and bloody stool. Ectodermal changes included skin pigmentation, alopecia, and nail dystrophy. Colonoscopy revealed the presence of multiple polyps. After a comprehensive evaluation, the patient was diagnosed with CCS. During the disease, he was also diagnosed with pulmonary embolism, Riehl's melanosis, and intestinal flora imbalance. After symptomatic treatment with omeprazole, mesalazine, rivaroxaban, nutritional support, and regulation of intestinal flora, the patient’s symptoms were significantly relieved.
CONCLUSION
CCS complicated with PE was reported for the first time in China in this study. Despite the fact that CCS is extremely rare, patients with CCS should be classified as a high-risk venous thromboembolism (VTE) population, and emphasis should be placed on venous thromboembolism risk assessment and stratification, deep venous thromboembolism screening, prevention of VTE, and careful long-term follow-up.
Core Tip: The case report is a rare and complex case of Cronkhite-Canada syndrome (CCS) with pulmonary embolism. We completely recorded the whole process of the occurrence and development of the CCS and carried out follow-up observation. Without hormone treatment, the disease was cured through routine treatment. Patients with CCS have a higher risk of developing venous thromboembolism. We put forward a new view that patients with CCS should focus on preventing the occurrence of venous thromboembolism.
