Scientometrics
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2024; 12(21): 4726-4741
Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4726
Trends and frontiers in signal amplification for aptamer-based tumor detection: A bibliometric analysis
Dan Cai, Gui-Lin Chen, Ting Wang, Kun-He Zhang
Dan Cai, Ting Wang, Kun-He Zhang, Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Dan Cai, Ting Wang, Kun-He Zhang, Jiangxi Institute of Gastroenterology and Hepatology, Nanchang 330006, Jiangxi Province, China
Gui-Lin Chen, Department of Anorectal Surgery, The 908th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Nanchang 330000, Jiangxi Province, China
Author contributions: Cai D, Chen GL, Wang T, and Zhang KH participated in the conception and design of the study. Cai D, Chen GL, and Wang T acquired the data; Cai D and Chen GL performed statistical analysis and drafted the manuscript; Cai D and Wang T conducted the reference review; Cai D and Zhang KH revised the manuscript. All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82160494 and No. 82160444.
Conflict-of-interest statement: The authors declare no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2020 Checklist, and the manuscript was prepared and revised according to the PRISMA 2020 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kun-He Zhang, Doctor, Doctor, Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, No. 17, Yongwai Zheng Street, Nanchang 330006, Jiangxi Province, China. zhangkh789@163.com
Received: March 29, 2024
Revised: May 22, 2024
Accepted: June 7, 2024
Published online: July 26, 2024
Processing time: 93 Days and 0.2 Hours
Abstract
BACKGROUND

Malignant tumors are one of the leading causes of death worldwide, imposing a substantial economic and social burden. Early detection is the key to improving cure rates and reducing mortality rates, which requires the development of sensitive early detection technologies. Signal amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from researchers.

AIM

To investigate the current research status, developmental trajectories, and hotspots in signal amplification for aptamer-based tumor detection through bibliometric analysis.

METHODS

English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection database. VOSviewer and CiteSpace software were employed to analyze various information within this field, including countries, institutions, authors, co-cited authors, journals, co-cited journals, cited references, and keywords.

RESULTS

A total of 757 publications were included in this study. China accounted for 85.47% of all publications, with Nanjing University (China) emerging as the institution with the highest publication output. The most influential authors and journals were Hasanzadeh M. from Iran and "Biosensors and Bioelectronics", respectively. Exosomes and carcinoembryonic antigen (CEA) stood out as the most researched tumor-related molecules. Currently, the predominant signal amplification technique, nanomaterial, and signal transduction method were identified as hybridization chain reactions, gold nanoparticles, and electrochemical methods, respectively. Over the past 3 years, exosomes, CEA, electrochemical biosensors, and nanosheets have emerged as research hotspots, exhibiting a robust burst of intensity.

CONCLUSION

This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status, hotspots, and prospective research directions within this realm. Additionally, it provides an important reference for researchers.

Keywords: Aptamer, Signal amplification, Tumor, Bibliometrics, Electrochemistry, Nanosheet

Core Tip: This study is the first bibliometric analysis of the literature pertaining to signal amplification in aptamer-based tumor detection. It unveils that China accounts for 85.47% of all publications, with Hasanzadeh M of Iran and the journal "Biosensors and Bioelectronics". Furthermore, it highlights exosomes and carcinoembryonic antigen as the most extensively studied tumor-related molecules.