Tan FF, Liu HX, Huang XY, Yu CY, Yang XY. Atypical Guillain-Barré syndrome with positive anti-sulfatide, anti-GT1b, and anti-GT1a antibodies: A case report. World J Clin Cases 2024; 12(20): 4372-4376 [DOI: 10.12998/wjcc.v12.i20.4372]
Corresponding Author of This Article
Xiao-Yan Yang, Doctor, PhD, Chief Physician, Department of Neurology, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. 18984215060@163.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 16, 2024; 12(20): 4372-4376 Published online Jul 16, 2024. doi: 10.12998/wjcc.v12.i20.4372
Atypical Guillain-Barré syndrome with positive anti-sulfatide, anti-GT1b, and anti-GT1a antibodies: A case report
Fei-Fei Tan, He-Xu Liu, Xue-Yan Huang, Chang-Yin Yu, Xiao-Yan Yang
Fei-Fei Tan, He-Xu Liu, Xue-Yan Huang, Chang-Yin Yu, Xiao-Yan Yang, Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Co-corresponding authors: Chang-Yin Yu and Xiao-Yan Yang.
Author contributions: Tan FF wrote the original draft; Liu HX and Huang XY contributed to clinical data collection; Yu CY and Yang XY contributed to conceptualization, supervision, and manuscript review and editing; all authors reviewed the manuscript; all authors read, revised, and approved the final manuscript.
Supported byThe Scientific and Technological Innovation Talent Team Project of Zunyi City, No. [2022] 2; and Guizhou Maotai Hospital Research and Talent Cultivation Funding Project, No. MTYK 2022-06.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this case report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Yan Yang, Doctor, PhD, Chief Physician, Department of Neurology, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. 18984215060@163.com
Received: March 20, 2024 Revised: May 13, 2024 Accepted: May 21, 2024 Published online: July 16, 2024 Processing time: 101 Days and 10 Hours
Abstract
BACKGROUND
The role of diverse antibodies in mediating peripheral nerve injury in Guillain-Barré syndrome (GBS) is becoming clearer, but positivity for multiple antibodies in one case is uncommon. To our knowledge, this is the first case involving GBS with positive anti-sulfatide, anti-GT1a, and anti-GT1b antibodies.
CASE SUMMARY
A 20-year-old female patient was admitted to the hospital due to weakness of limbs for 5 d, and deterioration of the weakness and muscle aches for 1 d. The patient's limbs were weak, but the tendon reflexes in the part of the limbs were normal. There was no comorbid peripheral nociception or deep sensory dysfunction. She was diagnosed with GBS and was discharged after receiving intravenous human immunoglobulin pulse therapy.
CONCLUSION
In this article, the clinical manifestations, neurophysiological examination, and auxiliary examination findings of a GBS patient positive for multiple antibodies were analyzed to improve the identification of the disease by clinical physicians at an early stage.
Core Tip: Guillain-Barré syndrome (GBS) is an acquired acute autoimmune polyneuropathy. Different positive antibodies have different clinical characteristics, and multiple positive antibodies in a case is very rare. This paper reports the clinical characteristics of a GBS case positive for multiple antibodies, to guide clinicians in early identification and diagnosis of such rare cases.
