Ning FF, Yao TT, Wang XX. Application of dezocine patient-controlled epidural analgesia in postoperative analgesia in patients with total myomectomy. World J Clin Cases 2024; 12(20): 4265-4271 [DOI: 10.12998/wjcc.v12.i20.4265]
Corresponding Author of This Article
Xiao-Xia Wang, MSc, Associate Chief Physician, Department of Gynaecology, Gansu Provincial Maternity and Child-Care Hospital, No. 143 Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China. wangxx15692022@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Randomized Clinical Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 16, 2024; 12(20): 4265-4271 Published online Jul 16, 2024. doi: 10.12998/wjcc.v12.i20.4265
Application of dezocine patient-controlled epidural analgesia in postoperative analgesia in patients with total myomectomy
Feng-Feng Ning, Ting-Ting Yao, Xiao-Xia Wang
Feng-Feng Ning, Department of Anesthesiology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730050, Gansu Province, China
Ting-Ting Yao, Xiao-Xia Wang, Department of Gynecology, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, Gansu Province, China
Author contributions: Ning FF and Wang XX designed the research; Ning FF and Yao TT performed the research; Ning FF and Wang XX analyzed the data and wrote the manuscript.
Supported byNatural Science Foundation of Gansu Provincial Science and Technology Department (Basic Research Program), No. 23JRRA1385.
Institutional review board statement: This study was approved by the institutional review board of Gansu Maternal and Child Health Hospital.
Informed consent statement: Informed consent has been obtained from each participant before enrolment in the study.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Data sharing statement: The relevant data can be obtained from the corresponding author upon request.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Xia Wang, MSc, Associate Chief Physician, Department of Gynaecology, Gansu Provincial Maternity and Child-Care Hospital, No. 143 Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China. wangxx15692022@163.com
Received: April 8, 2024 Revised: May 8, 2024 Accepted: May 29, 2024 Published online: July 16, 2024 Processing time: 82 Days and 14.1 Hours
Abstract
BACKGROUND
Uterine fibroids are common benign gynecological conditions. Patients who experience excessive menstruation, anemia, and pressure symptoms should be administered medication, and severe cases require a total hysterectomy. This procedure is invasive and causes severe postoperative pain, which can affect the patient’s postoperative sleep quality and, thus, the recovery process.
AIM
To evaluate use of dezocine in patient-controlled epidural analgesia (PCEA) for postoperative pain management in patients undergoing total myomectomy.
METHODS
We selected 100 patients undergoing total abdominal hysterectomy for uterine fibroids and randomized them into two groups: a control group receiving 0.2% ropivacaine plus 0.06 mg/mL of morphine and an observation group receiving 0.2% ropivacaine plus 0.3 mg/mL of diazoxide in their PCEA. Outcomes assessed included pain levels, sedation, recovery indices, PCEA usage, stress factors, and sleep quality.
RESULTS
The observation group showed lower visual analog scale scores, shorter postoperative recovery indices, fewer mean PCEA compressions, lower cortisol and blood glucose levels, and better polysomnographic parameters compared to the control group (P < 0.05). The cumulative incidence of adverse reactions was lower in the observation group than in the control group (P < 0.05).
CONCLUSION
Dezocine PCEA can effectively control the pain associated with total myomectomy, reduce the negative impact of stress factors, and have less impact on patients’ sleep, consequently resulting in fewer adverse effects.
Core Tip: This study investigated the role of dezocine patient-controlled epidural analgesia (PCEA) in managing pain after total hysteromyectomy. Preliminary studies have found that dezocine PCEA can effectively control pain after the procedure, reduce the negative impact of stress factors, improve patients’ sleep quality, and result in fewer adverse reactions. The results of this study provide valuable insights for clinical anesthesia practices.
