Jiang X, Chen J, Gu FF, Li ZR, Song YS, Long JJ, Zhang SZ, Xu TT, Tang YJ, Gu JY, Fang XM. Evaluating the efficacy of percutaneous puncture biopsy guided by contrast-enhanced ultrasound for peripheral pulmonary lesions. World J Clin Cases 2024; 12(19): 3791-3799 [PMID: 38994323 DOI: 10.12998/wjcc.v12.i19.3791]
Corresponding Author of This Article
Ji-Ying Gu, MS, Doctor, Department of Ultrasonography, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, No. 999 Shiguang Road, Shanghai 200438, China. gjy2552@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao Jiang, Fang-Fang Gu, Zhong-Rong Li, Yu-Shan Song, Jing-Jing Long, Shu-Zhen Zhang, Ting-Ting Xu, Yong-Jun Tang, Ji-Ying Gu, Department of Ultrasonography, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai 200438, China
Xiao Jiang, Jun Chen, Department of Ultrasonography, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, Jiangsu Province, China
Xiang-Ming Fang, Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, Jiangsu Province, China
Co-corresponding authors: Ji-Ying Gu and Xiang-Ming Fang.
Author contributions: Jiang X designed and performed the research; Gu JY and Fang XM designed the research and supervised the report; Jiang X, Chen J, Gu FF, Li ZR, Song YS, Long JJ, Zhang SZ, Xu TT, Tang YJ, Gu JY and Fang XM collected and analyzed data; all authors approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Wuxi People's Hospital (No. KY17071).
Informed consent statement: As the study used anonymous and pre-existing data, the requirement for the informed consent from patients was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The labeled dataset used to support the findings of this study are available from the corresponding author upon request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-Ying Gu, MS, Doctor, Department of Ultrasonography, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, No. 999 Shiguang Road, Shanghai 200438, China. gjy2552@126.com
Received: March 14, 2024 Revised: May 14, 2024 Accepted: May 24, 2024 Published online: July 6, 2024 Processing time: 106 Days and 19.7 Hours
Abstract
BACKGROUND
The incidence and mortality of lung cancer have increased annually. Accurate diagnosis can help improve therapeutic efficacy of interventions and prognosis. Percutaneous lung biopsy is a reliable method for the clinical diagnosis of lung cancer. Ultrasound-guided percutaneous lung biopsy technology has been widely promoted and applied in recent years.
AIM
To investigate the diagnostic value of contrast-enhanced ultrasound (CEUS)-guided percutaneous biopsy in peripheral pulmonary lesions.
METHODS
We retrospectively collected data on 237 patients with peripheral thoracic focal lesions who underwent puncture biopsy at Wuxi People’s Hospital. The patients were randomly divided into two groups: The CEUS-guided before lesion puncture group (contrast group) and conventional ultrasound-guided group (control group). Analyze the diagnostic efficacy of the puncture biopsy, impact of tumor size, and number of puncture needles and complications were analyzed and compared between the two groups.
RESULTS
Accurate pathological results were obtained for 92.83% (220/237) of peripheral lung lesions during the first biopsy, with an accuracy rate of 95.8% (113/118) in the contrast group and 89.9% (107/119) in the control group. The difference in the area under the curve (AUC) between the contrast and the control groups was not statistically significant (0.952 vs 0.902, respectively; P > 0.05). However, when the lesion diameter ≥ 5 cm, the diagnostic AUC of the contrast group was higher than that of the control group (0.952 vs 0.902, respectively; P < 0.05). In addition, the average number of puncture needles in the contrast group was lower than that in the control group (2.58 ± 0.53 vs 2.90 ± 0.56, respectively; P < 0.05).
CONCLUSION
CEUS guidance can enhance the efficiency of puncture biopsy of peripheral pulmonary lesions, especially for lesions with a diameter ≥ 5 cm. Therefore, CEUS guidance has high clinical diagnostic value in puncture biopsy of peripheral focal lung lesions.
Core Tip: Percutaneous lung biopsy is the most reliable method for clinical diagnosis of lung cancer. In this study, the data of patients with peripheral thoracic focal lesions were collected retrospectively, and comparisons were made between conventional ultrasound-guided examination (control) and contrast-enhanced ultrasound (CEUS)-guided percutaneous biopsy in the diagnosis of peripheral pulmonary lesions. The results showed that CEUS guidance can improve the efficiency and provide significant diagnostic value for puncture biopsy of peripheral pulmonary lesions.
