Zhang KC, Chu SY, Ding DC. High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report. World J Clin Cases 2024; 12(18): 3539-3547 [DOI: 10.12998/wjcc.v12.i18.3539]
Corresponding Author of This Article
Dah-Ching Ding, MD, PhD, Director, Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, No. 707 Chung-Yang Road, Hualien 970, Taiwan. dah1003@yahoo.com.tw
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2024; 12(18): 3539-3547 Published online Jun 26, 2024. doi: 10.12998/wjcc.v12.i18.3539
High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality: A case report
Kai-Cheng Zhang, Shao-Yin Chu, Dah-Ching Ding
Kai-Cheng Zhang, Dah-Ching Ding, Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan
Shao-Yin Chu, Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan
Dah-Ching Ding, Institute of Medical Sciences, Tzu Chi University, Hualien 970, Taiwan
Author contributions: Ding DC contributed to conceptualization, methodology, formal analysis, writing-original draft preparation, and writing, review, and editing; Zhang KC contributed to data curation and prepared the original draft; Chu SY contributed to data curation and prepared the original draft. All the authors have read and agreed to the published version of the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this paper.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016)
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dah-Ching Ding, MD, PhD, Director, Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, No. 707 Chung-Yang Road, Hualien 970, Taiwan. dah1003@yahoo.com.tw
Received: December 29, 2023 Revised: April 23, 2024 Accepted: May 7, 2024 Published online: June 26, 2024 Processing time: 172 Days and 0.8 Hours
Abstract
BACKGROUND
Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome. This study presents a rare association between chromosome 4q abnormalities and fallopian tube high-grade serous carcinoma (HGSC) in a young woman.
CASE SUMMARY
A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion. Upon arrival at the emergency room, her abdomen appeared ovoid and distended with palpable shifting dullness. Ascites were identified through abdominal ultrasound, and computed tomography revealed an omentum cake and an enlarged bilateral adnexa. Blood tests showed elevated CA-125 levels. Paracentesis was conducted, and immunohistochemistry indicated that the cancer cells favored an ovarian origin, making us suspect ovarian cancer. The patient underwent debulking surgery, which led to a diagnosis of stage IIIC HGSC of the fallopian tube. Subsequently, the patient received adjuvant chemotherapy with carboplatin and paclitaxel, resulting in stable current condition.
CONCLUSION
This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC. UBE2D3 may affect crucial cancer-related pathways, including P53, BRCA, cyclin D, and tyrosine kinase receptors, thereby possibly contributing to cancer development. In addition, ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.
Core Tip: In this report, we present a case of high-grade serous carcinoma (HGSC) in the fallopian tube of a young woman, associated with a chromosomal 4q abnormality. We provide updated insights on the symptoms, signs, diagnosis, and treatment specific to HGSC linked with chromosomal abnormalities. Given the rare nature of chromosomal abnormality-associated HGSC, we have formulated a strategic approach for its diagnosis and management.
