Huang DH, Hu YX, Guo S, Yang WJ. Prostate cancer with elevated free prostate-specific antigen density: A case report. World J Clin Cases 2024; 12(17): 3259-3264 [PMID: 38898853 DOI: 10.12998/wjcc.v12.i17.3259]
Corresponding Author of This Article
Wen-Jiang Yang, MM, Doctor, Department of Urological Surgical, Wenshang County People's Hospital, No. 1 Dehui Road, Jining 272500, Shandong Province, China. 371993879@qq.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 16, 2024; 12(17): 3259-3264 Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.3259
Prostate cancer with elevated free prostate-specific antigen density: A case report
Deng-Hui Huang, Yun-Xi Hu, Shuang Guo, Wen-Jiang Yang
Deng-Hui Huang, Yun-Xi Hu, Shuang Guo, Wen-Jiang Yang, Department of Urological Surgical, Wenshang County People's Hospital, Jining 272500, Shandong Province, China
Author contributions: Huang DH performed the data analysis and writing the first draft of the paper; Hu YX and Guo S participated in data sorting and chart processing; Huang DH and Yang WJ completed the conception, revision and finalizing of the paper; Yang WJ was the designer of this research program and the person in charge of the research work, and was responsible for the arrangement and writing of the first draft of the paper. All authors read and agree to the final text.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this article and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Jiang Yang, MM, Doctor, Department of Urological Surgical, Wenshang County People's Hospital, No. 1 Dehui Road, Jining 272500, Shandong Province, China. 371993879@qq.com
Received: March 2, 2024 Revised: April 21, 2024 Accepted: April 28, 2024 Published online: June 16, 2024 Processing time: 94 Days and 2 Hours
Abstract
BACKGROUND
Prostate cancer is the second most common cancer among men worldwide, and prostate-specific antigen (PSA) is often used in clinical practice to screen for prostate cancer. Normal total PSA (tPSA) level initially excludes prostate cancer. Here, we report a case of prostate cancer with elevated free PSA density (fPSAD).
CASE SUMMARY
A patient diagnosed with benign prostatic hyperplasia underwent prostatectomy, and the postoperative pathological results showed acinar adenocarcinoma of the prostate. The patient is currently undergoing endocrine chemotherapy.
CONCLUSION
We provide a clinical reference for diagnosis and treatment of patients with normal tPSA but elevated fPSAD.
Core Tip: The patient was diagnosed with prostatic hyperplasia before surgery, and the postoperative pathological findings suggested prostate cancer. Total prostate-specific antigen (PSA) was within the normal range, while free PSA density (fPSAD) was elevated. We emphasize that PSA levels < 4 ng/mL may not always correlate with low cancer risk, highlighting the importance of fPSAD.
