Chidzonga MM, Mahomva L, Zambuko B, Muungani W. Pleomorphic adenoma (mixed tumor) of the upper lip: A case report. World J Clin Cases 2024; 12(17): 3138-3143 [PMID: 38898865 DOI: 10.12998/wjcc.v12.i17.3138]
Corresponding Author of This Article
Midion Mapfumo Chidzonga, DDS, Full Professor, Department of Oral Health, University of Zimbabwe Faculty of Medicine and Health Sciences and Lancet Laboratory, Mazowe Street, Harare, Zimbabwe. mtmchidzonga@yahoo.com
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 16, 2024; 12(17): 3138-3143 Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.3138
Pleomorphic adenoma (mixed tumor) of the upper lip: A case report
Midion Mapfumo Chidzonga, Leonard Mahomva, Blessing Zambuko, Welcome Muungani
Midion Mapfumo Chidzonga, Leonard Mahomva, Blessing Zambuko, Welcome Muungani, Department of Oral Health, University of Zimbabwe Faculty of Medicine and Health Sciences and Lancet Laboratory, Harare, Zimbabwe
Author contributions: Chidzonga MM contributed to conception of the idea of the case report and first draft preparation; Chidzonga MM, Mahomva L, and Muungani W contributed to surgical management and patient care; Chidzonga MM and Mahomva L contributed to literature review; Zambuko B contributed to the histopathology examination, diagnosis, and preparation of photomicrographs; Chidzonga MM, Mahomva L, Zambuko B, and Muungani W revised and finalized the manuscript.
Informed consent statement: Informed written consent was obtained from the patient and the Joint Research Ethics Committee of the University of Zimbabwe Faculty of Medicine and Health Sciences and Parirenyatwa Group of Hospitals.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Midion Mapfumo Chidzonga, DDS, Full Professor, Department of Oral Health, University of Zimbabwe Faculty of Medicine and Health Sciences and Lancet Laboratory, Mazowe Street, Harare, Zimbabwe. mtmchidzonga@yahoo.com
Received: January 12, 2024 Revised: March 25, 2024 Accepted: April 16, 2024 Published online: June 16, 2024 Processing time: 144 Days and 3 Hours
Abstract
BACKGROUND
Salivary gland tumors are relatively rare. Most minor salivary gland tumors are malignant with benign tumors accounting for 18% of the tumors. Pleomorphic adenoma (PA) is the most common salivary gland tumor. Lip PA is uncommon with 9.8% occurring in the upper lip. We are adding on the knowledge of the rare upper lip PA (benign mixed tumor).
CASE SUMMARY
We report an upper lip PA (benign mixed tumor) in a 28-year-old man. His complaint was a painless swelling on the upper lip. A painless, non-tender, well-circumscribed, slightly mobile, sessile, nodular, and rubbery (in consistency) tumor measuring 5.0 cm x 2.0 cm was noted on the left side of his upper lip. The overlying skin was not fixed and of normal color. There was no ulceration, and palpation did not elicit pain or bleeding. There was no history of trauma. Blunt dissection was used to completely excise the nodular, whitish, and encapsulated tumor. Microscopy showed a well-circumscribed and partly encapsulated biphasic lesion, with large lobules of myxo-chondroid stroma and intervening cellular nodules of basaloid cells, well-formed tubules containing eosinic secretion, and nests of myoepithelial cells. A diagnosis of PA (benign mixed tumor) was confirmed.
CONCLUSION
Blunt dissection is indicated to preserve the cosmesis and function of the upper lip.
Core Tip: Salivary gland tumors are relatively rare. Pleomorphic adenoma (PA) (benign mixed tumor) is the most common benign tumor of the salivary glands. It comprises about 3%-10% of all head and neck tumors and 50% of the major and minor salivary gland neoplasms. Among minor salivary gland tumors, the palate is the most common site of predilection (42.8%-68.8%), followed by the upper lip (15%-20%). PA of the upper lip is relatively rare. Our case report is on the clinical presentation, histopathology, and management of PA (benign mixed tumor) of the upper lip.
