Yin Y, Yao Y, Li YJ, Zhao LL, Zhang Q. Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer. World J Clin Cases 2024; 12(17): 3045-3052 [PMID: 38898875 DOI: 10.12998/wjcc.v12.i17.3045]
Corresponding Author of This Article
Yue Yin, MM, Deputy chief physician, Doctor, Department of Stomatology, North China University of Science and Technology Affiliated Hospital, No. 73 South Construction Road, Lubei District, Tangshan 063000, Hebei Province, China. yangzhinian1983@163.com
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yue Yin, Yuan Yao, Yi-Jie Li, Li-Li Zhao, Qiang Zhang, Department of Stomatology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, Hebei Province, China
Author contributions: Yin Y, Yao Y and Li YJ designed the study; Zhao LL and Zhang Q performed the data collection and analysed the data, and Yin Y wrote the manuscript; All authors reviewed the manuscript.
Supported bythe Hebei Province Traditional Chinese Medicine Research Programme Project, No. 2022428.
Institutional review board statement: The study was approved by the Medical Ethics Committee of the North China University of Science and Technology Affiliated Hospital.
Informed consent statement: This study exclusively involved the use of non-identifiable patient data that does not compromise patient privacy. All data collected, recorded, and managed were strictly for research purposes and posed no harm to the participants. Consequently, the ethics committee of the North China University of Science and Technology Affiliated Hospital waived the requirement for informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: Original data should be obtained by contacting the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Yin, MM, Deputy chief physician, Doctor, Department of Stomatology, North China University of Science and Technology Affiliated Hospital, No. 73 South Construction Road, Lubei District, Tangshan 063000, Hebei Province, China. yangzhinian1983@163.com
Received: March 4, 2024 Revised: April 24, 2024 Accepted: May 7, 2024 Published online: June 16, 2024 Processing time: 92 Days and 7.9 Hours
Abstract
BACKGROUND
Oral cancer, which is caused by mucous membrane variation, represents a prevalent malignant tumor in the oral and maxillofacial region, posing a significant threat to patients’ lives and safety. While surgical intervention stands as a cornerstone treatment for oral cancer patients, it carries the risk of incomplete treatment or high rates of postoperative recurrence. Hence, a multifaceted approach incorporating diverse treatment modalities is essential to enhance patient prognosis.
AIM
To analyze the application effect of Tongluo Jiedu prescription as adjuvant therapy and its influence on patient prognosis in patients with oral cancer.
METHODS
Eighty oral cancer patients in our hospital were selected and divided into the observation group and control group by a random number table. The control group was treated with continuous arterial infusion chemotherapy of cisplatin and 5-fluorouracil. The observation group was additionally given Tongluo Jiadu prescription. The inflammatory stress level, peripheral blood T-cell subsets, and immune function of the two groups were subsequently observed. SPSS 21.0 was used for data analysis.
RESULTS
The observation group demonstrated lower levels of interleukin-6 and C-reactive protein, and a higher level of tumor necrosis factor in comparison to the control group. After treatment, the immune function in the observation group was significantly better than in the control group.
CONCLUSION
Tongluo Jiedu prescription can improve the immune function and oxidative stress level of patients with oral cancer and accelerate the recovery process.
Core Tip: This study prospectively selected 80 patients with oral cancer, and used collateral detoxification as an auxiliary means for continuous arterial perfusion chemotherapy. Tongluo Jiedu prescription improved the immune function and oxidative stress level of patients with oral cancer and accelerated the recovery process.
