Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.3019
Revised: April 17, 2024
Accepted: April 19, 2024
Published online: June 16, 2024
Processing time: 96 Days and 7.3 Hours
Chronic eczema significantly impacts daily life, social interactions, and quality of life; however, no curative treatment has been identified.
To determine the clinical efficacy of acupoint injection for chronic eczema and its influence on peripheral blood T cells.
Eighty patients with chronic eczema treated at our hospital between June 2022 and March 2023 were randomly assigned to a control group (n = 40), which rec
No difference in overall response rates were found between the observation and control groups (100% vs 90%, respectively; P > 0.05); however, the observation group had a higher marked response rate than the control group (87.5% vs 52.5%; P < 0.05). Both groups had decreased Eczema Area and Severity Index scores and increased pruritus after treatment (P < 0.05), particularly in the observation group (P < 0.05). The observation group had an adverse reaction rate of 2.5% (1/40), which did not differ significantly from that of the control group (P > 0.05). The observation group exhibited higher post-treatment INF-γ and IL-2 but lower IL-4 levels than the control group (P < 0.05); however, no significant inter-group difference was observed in post-treatment IL-10 levels (P > 0.05).
Acupoint injection of triamcinolone acetonide is safe and effective in treating chronic eczema. Its therapeutic mechanism is related to the regulation of peripheral blood T cell levels, inhibition of inflammatory reactions, and mitigation of immune imbalance.
Core Tip: No cure has been found for chronic eczema. In this study, patients with eczema were treated with either routine Western medicine treatment or routine Western medicine treatment plus acupoint injection of triamcinolone acetonide. The clinical efficacy of the two treatment regimens was validated based on therapeutic efficacy, incidence of adverse reactions, and changes in serum cytokine INF-γ and IL-2/4/10 levels before and after treatment. Acupoint injection of triamcinolone acetonide was found safe and effective in treating chronic eczema, and its therapeutic mechanism is related to regulating peripheral blood T cell levels, inhibiting inflammatory reactions, and regulating immune imbalance.