Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.2976
Revised: April 22, 2024
Accepted: April 23, 2024
Published online: June 16, 2024
Processing time: 89 Days and 7.4 Hours
Diabetic foot ulcers (DFUs) are a common complication of diabetes, often leading to severe infections, amputations, and reduced quality of life. The current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications. A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with DFUs. The hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing, reduced amputation rates, and improved overall patient outcomes compared to standard treatment protocols.
To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol.
This retrospective study included 62 patients with DFUs, enrolled between January 2022 and January 2024, randomly assigned to the experimental (n = 32) or control (n = 30) group. The experimental group received a comprehensive treatment comprising blood circulation improvement, debridement, vacuum sealing drainage, recombinant human epidermal growth factor and anti-inflammatory dressing, and skin grafting. The control group received standard treat
The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate, wound healing time, and amputation rate. Additionally, the comprehensive treatment protocol was safe and well tolerated by the patients.
Comprehensive treatment for DFUs is more effective than standard treatment, promoting granulation tissue growth, shortening hospitalization time, reducing pain and amputation rate, improving wound healing, and enhancing quality of life.
Core Tip: That a comprehensive treatment protocol for diabetic foot ulcers (DFUs) yields superior outcomes compared to standard treatment. The protocol involving interventions for improving blood circulation, debridement, vacuum-sealing drainage, growth factor dressing, and skin grafting, resulted in faster wound healing, reduced amputation rates, and enhanced quality of life. These findings underscore the importance of implementing a comprehensive treatment approach to DFU management to promote granulation tissue growth, shorten hospital stays, alleviate pain, and improve wound healing. In this study, patients who received comprehensive treatment experienced significantly better wound healing rates, shorter healing times, and lower amputation rates than those of patients who received standard treatment.