Huang LN, Deng X, Xu J. Uterine epithelioid trophoblastic tumor with the main manifestation of increased human chorionic gonadotropin: A case report. World J Clin Cases 2024; 12(16): 2876-2880 [PMID: 38899287 DOI: 10.12998/wjcc.v12.i16.2876]
Corresponding Author of This Article
Li-Na Huang, MS, Department of Gynecology, Ningbo Women and Children's Hospital, No. 339 Liuting Street, Haishu District, Ningbo 315012, Zhejiang Province, China. hln314@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2024; 12(16): 2876-2880 Published online Jun 6, 2024. doi: 10.12998/wjcc.v12.i16.2876
Uterine epithelioid trophoblastic tumor with the main manifestation of increased human chorionic gonadotropin: A case report
Li-Na Huang, Xi Deng, Jian Xu
Li-Na Huang, Department of Gynecology, Ningbo Women and Children's Hospital, Ningbo 315012, Zhejiang Province, China
Xi Deng, Department of Ningbo Clinical Pathology Diagnosis Center, Ningbo 315021, Zhejiang Province, China
Jian Xu, Department of Imaging, Ningbo Women and Children's Hospital, Ningbo 315012, Zhejiang Province, China
Author contributions: Huang LN conducted the studies, collected data, and drafted the manuscript; Deng X and Xu J participated in acquiring, analyzing, or interpreting data and drafting the manuscript. All authors have read and approve the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Na Huang, MS, Department of Gynecology, Ningbo Women and Children's Hospital, No. 339 Liuting Street, Haishu District, Ningbo 315012, Zhejiang Province, China. hln314@163.com
Received: January 31, 2024 Revised: April 3, 2024 Accepted: April 18, 2024 Published online: June 6, 2024 Processing time: 118 Days and 23.1 Hours
Abstract
BACKGROUND
Epithelioid trophoblastic tumor (ETT) is an extremely rare malignant gestational trophoblastic neoplasm commonly presenting with abnormal vaginal bleeding, abdominal pain, and increased human chorionic gonadotropin (hCG). This study reported a case of uterine ETT with the main manifestation being increased hCG.
CASE SUMMARY
A 39-year-old female was referred to the Ningbo Maternal and Child Hospital of China in December 2022, complaining of increased hCG levels for 1 month. Magnetic resonance imaging revealed gestational trophoblastic tumor, and hysteroscopic electrotomy and curettage of intrauterine hyperplasia were performed. The patient was diagnosed with uterine ETT through postoperative pathological examination and immunohistochemical results. Total laparoscopic hysterectomy and bilateral salpingectomy were performed, and hCG levels returned to normal. The patient was without recurrence during the postoperative 3-month follow-up.
CONCLUSION
This study reported a case of uterine ETT with the main manifestation being increased hCG, highlighting that ETT should be considered in the presence of abnormal hCG. A total laparoscopic hysterectomy is recommended.
Core Tip: This study presents a rare case of uterine epithelioid trophoblastic tumor (ETT) with elevation of human chorionic gonadotropin (hCG) as the only sign. The patient, initially misdiagnosed with gestational trophoblastic tumor, underwent a successful total laparoscopic hysterectomy, emphasizing the significance of considering ETT in cases with abnormal hCG. The study highlights the diagnostic challenges posed by ETT and advocates for total laparoscopic hysterectomy as a recommended treatment, contributing valuable insights for gynecologists facing similar cases.
